Evidence map›Paper›PMID 29471039›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2018

High-frequency, low-intensity ultrasound and microbubbles enhance nerve blockade.

Kathleen Cullion, Claudia M Santamaria, Changyou Zhan, David Zurakowski, Tao Sun, Grant L Pemberton, Nathan J McDannold, Daniel S Kohane

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Externally triggered drug delivery systems.Smart materials in medicine · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kathleen CullionLaboratory for Biomaterials and Drug Delivery, Division of Critical Care Medicine, Department of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Department of Medicine, Division of Medicine Critical Care, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Claudia M SantamariaLaboratory for Biomaterials and Drug Delivery, Division of Critical Care Medicine, Department of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Changyou ZhanDepartment of Pharmacology, School of Basic Medical Sciences, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai, China.
David ZurakowskiDepartment of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Tao SunFocused Ultrasound Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Grant L PembertonLaboratory for Biomaterials and Drug Delivery, Division of Critical Care Medicine, Department of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Department of Medicine, Division of Medicine Critical Care, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Nathan J McDannoldFocused Ultrasound Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Daniel S KohaneLaboratory for Biomaterials and Drug Delivery, Division of Critical Care Medicine, Department of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Department of Anesthesiology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States. Electronic address: Daniel.Kohane@childrens.harvard.edu.

Funding

Nanoparticle-driven systems for tunable local pain reliefR01GM116920 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI KOHANE, DANIEL S · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM116920
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MicrobubblesUltrasonographyAnimalsMaleNerve BlockRats, Sprague-DawleySciatic NerveTetrodotoxinTetrodotoxin

Identifiers

PMID29471039
PMCPMC5894346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.