ArticleEating and weight disorders : EWD2020
Body mass index is independently associated with xanthine oxidase activity in overweight/obese population.
Article in Eating and weight disorders : EWD, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 27 citations in OpenAlex.
- Expression profile of apolipoproteins (APOE) and endothelin-1 (ET-1) genes in ischemic heart disease.BMC cardiovascular disorders · 2026Article
- Oxidative stress in adolescents with overweight/obesity.Journal of medical biochemistry · 2026Article
- Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.Nature genetics · 2024Article
- Blood Pressure Patterns and Hepatosteatosis: Cardiometabolic Risk Assessment in Dipper and Non-Dipper Phenotypes.Journal of clinical medicine · 2024Article
- Evaluation of the relationship between xanthine oxidase activity and metabolic syndrome in a population group in Bangladesh.Scientific reports · 2024Article
- The Bioactivity and Phytochemicals ofInternational journal of molecular sciences · 2024Review
- Principal component analysis of the oxidative stress, inflammation, and dyslipidemia influence in patients with different levels of glucoregulation.Journal of medical biochemistry · 2023Article
- Malondialdehyde as an independent predictor of body mass index in adolescent girls.Journal of medical biochemistry · 2023Article
- Current Status of Obesity: Protective Role of Catechins.Antioxidants (Basel, Switzerland) · 2023Review
- Review
- Relationship between lipid accumulation product and oxidative biomarkers by gender in adults from Yucatan, Mexico.Scientific reports · 2022Article
- Oxidative stress and cardiometabolic biomarkers in patients with non-alcoholic fatty liver disease.Scientific reports · 2021Article
- Influence of xanthine oxidoreductase inhibitor, topiroxostat, on body weight of diabetic obese mice.Nutrition & diabetes · 2021Article
- The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity.Frontiers in cardiovascular medicine · 2021Review
- Oxidative Stress in Patients before and after On-Pump and Off-Pump Coronary Artery Bypass Grafting: Relationship with Syntax Score.Oxidative medicine and cellular longevity · 2021Article
- Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status Components in Adult Population.Oxidative medicine and cellular longevity · 2021Article
- The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia.International journal of molecular sciences · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity.
methodsA total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained.
resultsSignificant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = - 0.489, p < 0.001) are the independent predictors of XO activity (R
conclusionObesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. LEVEL OF EVIDENCE: Level V: cross-sectional descriptive study.
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