Trial reportAnnals of biomedical engineering2018
Estimated Brain Tissue Response Following Impacts Associated With and Without Diagnosed Concussion.
Trial report in Annals of biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Review of Cyclist Head Injury, Impact Characteristics and the Implications for Helmet Assessment Methods.Annals of biomedical engineering · 2023Pooled it
- Head Impact Research Using Inertial Sensors in Sport: A Systematic Review of Methods, Demographics, and Factors Contributing to Exposure.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The Effectiveness of Regulations and Behavioral Interventions on Head Impacts and Concussions in Youth, High-School, and Collegiate Football: A Systematized Review.Annals of biomedical engineering · 2020Pooled it
- In silico investigation of brain tissue responses associated with mild blast traumatic brain injury.Frontiers in bioengineering and biotechnology · 2026Article
- Data-driven standards for infant skull thickness distributions in computational modeling and analysis.Journal of anatomy · 2025Article
- Mechanical Characterisation of Grey, White, and Interface Behaviour in the Brain.Annals of biomedical engineering · 2025Article
- Finite element brain deformation in adolescent soccer heading.Computer methods in biomechanics and biomedical engineering · 2024Article
- Volumetric MRI Findings in Mild Traumatic Brain Injury (mTBI) and Neuropsychological Outcome.Neuropsychology review · 2023Review
- Consensus Head Acceleration Measurement Practices (CHAMP): Origins, Methods, Transparency and Disclosure.Annals of biomedical engineering · 2022Article
- Use of Brain Biomechanical Models for Monitoring Impact Exposure in Contact Sports.Annals of biomedical engineering · 2022Review
- Progressive long-term spatial memory loss following repeat concussive and subconcussive brain injury in mice, associated with dorsal hippocampal neuron loss, microglial phenotype shift, and vascular abnormalities.The European journal of neuroscience · 2021Article
- Instantaneous Whole-Brain Strain Estimation in Dynamic Head Impact.Journal of neurotrauma · 2021Article
- Purposeful Heading Performed by Female Youth Soccer Players Leads to Strain Development in Deep Brain Structures.Neurotrauma reports · 2021Article
- An Image Registration-Based Morphing Technique for Generating Subject-Specific Brain Finite Element Models.Annals of biomedical engineering · 2020Article
- Longitudinal white-matter abnormalities in sports-related concussion: A diffusion MRI study.Neurology · 2020Article
- A network-based response feature matrix as a brain injury metric.Biomechanics and modeling in mechanobiology · 2020Article
- Predicting Concussion Outcome by Integrating Finite Element Modeling and Network Analysis.Frontiers in bioengineering and biotechnology · 2020Article
- Novel strain analysis informs about injury susceptibility of the corpus callosum to repeated impacts.Brain communications · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Kinematic measurements of head impacts are sensitive to sports concussion, but not highly specific. One potential reason is these measures reflect input conditions only and may have varying degrees of correlation to regional brain tissue deformation. In this study, previously reported head impact data recorded in the field from high school and collegiate football players were analyzed using two finite element head models (FEHM). Forty-five impacts associated with immediately diagnosed concussion were simulated along with 532 control impacts without identified concussion obtained from the same players. For each simulation, intracranial response measures (max principal strain, strain rate, von Mises stress, and pressure) were obtained for the whole brain and within four regions of interest (ROI; cerebrum, cerebellum, brain stem, corpus callosum). All response measures were sensitive to diagnosed concussion; however, large inter-athlete variability was observed and sensitivity strength depended on measure, ROI, and FEHM. Interestingly, peak linear acceleration was more sensitive to diagnosed concussion than all intracranial response measures except pressure. These findings suggest FEHM may provide unique and potentially important information on brain injury mechanisms, but estimations of concussion risk based on individual intracranial response measures evaluated in this study did not improve upon those derived from input kinematics alone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.