ArticleProgress in biomaterials2013
Evaluation of silk sericin as a biomaterial: in vitro growth of human corneal limbal epithelial cells on Bombyx mori sericin membranes.
Article in Progress in biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- The Protective Effects of Silk Sericin Against Retinal Oxidative Stress:Molecules (Basel, Switzerland) · 2025Article
- Silver Cross-Linking of Silk Sericin-Based Hydrogels for Improved Stability and Broad-Spectrum Antimicrobial Properties.ACS applied bio materials · 2025Article
- Innovative Processing and Sterilization Techniques to Unlock the Potential of Silk Sericin for Biomedical Applications.Gels (Basel, Switzerland) · 2025Article
- Melatonin/Sericin Wound Healing Patches: Implications for Melanoma Therapy.International journal of molecular sciences · 2024Review
- Injectable Hydrogel Based on Gellan Gum/Silk Sericin for Application as a Retinal Pigment Epithelium Cell Carrier.ACS omega · 2022Article
- Study of the Antioxidative Effects ofMolecules (Basel, Switzerland) · 2022Article
- Silk ProteinsEnriched Nanocomposite Hydrogels Based on Modified MMT Clay and Poly(2-hydroxyethyl methacrylate-co-2-acrylamido-2-methylpropane Sulfonic Acid) Display Favorable Properties for Soft Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2022Article
- Research progress of natural silk fibroin and the application for drug delivery in chemotherapies.Frontiers in pharmacology · 2022Review
- Silk Hydrogel Substrate Stress Relaxation Primes Mesenchymal Stem Cell Behavior in 2D.ACS applied materials & interfaces · 2021Article
- In Vitro Interaction of Doxorubicin-Loaded Silk Sericin Nanocarriers with MCF-7 Breast Cancer Cells Leads to DNA Damage.Polymers · 2021Article
- The Human Tissue-Engineered Cornea (hTEC): Recent Progress.International journal of molecular sciences · 2021Review
- Hybrid Spider Silk with Inorganic Nanomaterials.Nanomaterials (Basel, Switzerland) · 2020Review
- Silk degumming time controls horseradish peroxidase-catalyzed hydrogel properties.Biomaterials science · 2020Article
- Artificial spinning of natural silk threads.Scientific reports · 2019Article
- Effects of silk fibroin in murine dry eye.Scientific reports · 2017Article
- Characterization of Bombyx mori and Antheraea pernyi silk fibroins and their blends as potential biomaterials.Progress in biomaterials · 2016Article
- Treatment of Silk Fibroin with Poly(ethylene glycol) for the Enhancement of Corneal Epithelial Cell Growth.Journal of functional biomaterials · 2015Article
- Key enzymes and proteins of crop insects as candidate for RNAi based gene silencing.Frontiers in physiology · 2015Review
- Silk Fibroin-Based Scaffold for Bone Tissue Engineering.Advances in experimental medicine and biologyArticle
- Further development of silk sericin as a biomaterial: comparative investigation of the procedures for its isolation fromProgress in biomaterialsArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sericin and fibroin are the two major proteins in the silk fibre produced by the domesticated silkworm, Bombyx mori. Fibroin has been extensively investigated as a biomaterial. We have previously shown that fibroin can function successfully as a substratum for growing cells of the eye. Sericin has been so far neglected as a biomaterial because of suspected allergenic activity. However, this misconception has now been dispelled, and sericin's biocompatibility is currently indisputable. Aiming at promoting sericin as a possible substratum for the growth of corneal cells in order to make tissue-engineered constructs for the restoration of the ocular surface, in this study we investigated the attachment and growth in vitro of human corneal limbal epithelial cells (HLECs) on sericin-based membranes. Sericin was isolated and regenerated from the silkworm cocoons by an aqueous procedure, manufactured into membranes, and characterized (mechanical properties, structural analysis, contact angles). Primary cell cultures from two donors were established in serum-supplemented media in the presence of murine feeder cells. Membranes made of sericin and fibroin-sericin blends were assessed in vitro as substrata for HLECs in a serum-free medium, in a cell attachment assay and in a 3-day cell growth experiment. While the mechanical characteristics of sericin were found to be inferior to those of fibroin, its ability to enhance the attachment of HLECs was significantly superior to fibroin, as revealed by the PicoGreen
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