Evidence map›Paper›PMID 29470605›Full record

ReviewPsychopharmacology2018

Considering the context: social factors in responses to drugs in humans.

Harriet de Wit, Michael Sayette

Abstract readReview
In one paragraph

Review in Psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
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  12. Role of social context in addiction etiology and recovery.Pharmacology, biochemistry, and behavior · 2023
    Review
  13. VR for Studying the Neuroscience of Emotional Responses.Current topics in behavioral neurosciences · 2023
    Article
  14. Harmful Drinking Phenotype in a Large Dutch Community Sample.Alcohol and alcoholism (Oxford, Oxfordshire) · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. The importance of psychology for shaping legal cannabis regulation.Experimental and clinical psychopharmacology · 2021
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Harriet de WitDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA. hdew@uchicago.edu.ORCID 0000-0002-7211-8994
Michael SayetteDepartments of Psychology and Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
University of Chicago · USUniversity of Pittsburgh · US

Funding

Determinants of Drug Preference in Humans--Administrative SupplementR01DA002812 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 1985 to 2024
$10.6M
Acquisition and persistence of drug cue conditioning in humans - Resubmission 01R01DA037011 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 2014 to 2018
$2.3M
NIDA NIH HHS R01 DA002812NIDA NIH HHS R01 DA037011
6 · The paper itself

Abstract

backgroundDrugs are typically used in social settings. Here, we consider two factors that may contribute to this observation: (i) the presence of other people may enhance the positive mood effects of a drug, and conversely, (ii) drugs may enhance the value of social stimuli.

methodsWe review evidence from controlled laboratory studies with human volunteers, which investigated either of these interactions between social factors and responses to drugs. We examine the bidirectional effects of social stimuli and single doses of alcohol, stimulants, opioids, and cannabis.

resultsAll four classes of drugs interact with social contexts, but the nature of these interactions varies across drugs, and depends on whether the context is positive or negative.

conclusionsAlcohol and stimulant drugs enhance the attractiveness of social stimuli and the desire to socialize, and social contexts, in turn, enhance these drugs' effects. In contrast, opioids and cannabis have subtler effects on social interactions and their effects are less influenced by the presence of others. Overall, there is stronger evidence that drugs enhance positive social contexts than that they dampen the negativity of unpleasant social settings. Controlled research is needed to understand the interactions between drugs of abuse and social contexts, to model and understand the determinants of drug use outside the laboratory.

Indexed as

CannabisSocial BehaviorAffectAnalgesics, OpioidCentral Nervous System StimulantsEthanolHumansSubstance-Related DisordersAnalgesics, OpioidCentral Nervous System StimulantsEthanolAlcoholCannabisContextHumanOpioidSocialStimulant

Identifiers

PMID29470605
PMCPMC5871591
OpenAlexW2791432596

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.