Evidence map›Paper›PMID 29470593›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2018

Increased Gi protein signaling potentiates the negative chronotropic effect of adenosine in the SHR right atrium.

Juliano Q D Rodrigues, Henrique Camara, Aron Jurkiewicz, Rosely O Godinho

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Juliano Q D RodriguesDepartment of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100-3° Andar, São Paulo, 04044-020, Brazil. juliano.quintella@unifesp.br.
Henrique CamaraDepartment of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100-3° Andar, São Paulo, 04044-020, Brazil.
Aron JurkiewiczDepartment of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100-3° Andar, São Paulo, 04044-020, Brazil.
Rosely O GodinhoDepartment of Pharmacology, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Três de Maio, 100-3° Andar, São Paulo, 04044-020, Brazil. godinho@unifesp.br.
Universidade Federal de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 309428/2015-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2013/20402-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/07019-4
6 · The paper itself

Abstract

Hypertension is a risk factor for cardiovascular diseases, which have been associated with dysfunction of sympathetic and purinergic neurotransmission. Therefore, herein, we evaluated whether modifications of adenosine receptor signaling may contribute to the cardiac dysfunction observed in hypertension. Isolated right atria from spontaneously hypertensive (SHR) or normotensive Wistar rats (NWR) were used to investigate the influence of adenosine receptor signaling cascade in the cardiac chronotropism. Our results showed that adenosine, the endogenous agonist of adenosine receptors, and CPA, a selective agonist of A

Indexed as

AdenosineAnimalsGTP-Binding Protein alpha Subunits, Gi-GoHeart AtriaHypertensionMaleRats, Inbred SHRRats, WistarReceptor, Adenosine A1Signal TransductionAdenosineGTP-Binding Protein alpha Subunits, Gi-GoReceptor, Adenosine A1Adenosine receptorG proteinHeart rateRight atriaSHR

Identifiers

PMID29470593
OpenAlexW2792273158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.