Trial reportPloS one2018
Association between HIV status and depressive symptoms among children and adolescents in the Southern Highlands Zone, Tanzania: A case-control study.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Prevalence and factors associated with common mental disorders in young people living with HIV in sub-Saharan Africa: a systematic review.Journal of the International AIDS Society · 2021Pooled it
- Psychiatric Disorders in Adolescents Living with HIV and Association with Antiretroviral Therapy Adherence in Sub-Saharan Africa: A Systematic Review and Meta-analysis.AIDS and behavior · 2021Pooled it
- The prevalence of depression among adolescent with HIV/AIDS: a systematic review and meta-analysis.AIDS research and therapy · 2021Pooled it
- The prevalence of mental health problems in sub-Saharan adolescents: A systematic review.PloS one · 2021Pooled it
- Exploratory Impact of iCARE Nigeria, a Combined mHealth and Peer Navigation Intervention, on Depressive Symptoms and Substance Use Among Youth Living With HIV in Nigeria: Single-Arm Trial.JMIR formative research · 2025Trial
- Evaluating potential mediators for the impact of a family-based economic intervention (Suubi+Adherence) on the mental health of adolescents living with HIV in Uganda.Social science & medicine (1982) · 2021Trial
- The value of hope: development and validation of a contextual measure of hope among people living with HIV in urban Tanzania a mixed methods exploratory sequential study.BMC psychology · 2020Trial
- Peer-led interventions: Exploring the peer group leader experience of delivering Sauti ya Vijana, a group-based mental health intervention for youth living with HIV in Tanzania.PLOS mental health · 2026Article
- Prevalence of depressive symptoms among secondary school adolescents in Dodoma and Pwani, Tanzania.PLOS mental health · 2026Article
- Generalized and COVID-19 related anxiety among Tanzanian adolescents with HIV and association with HIV outcomes during the COVID-19 pandemic.BMC public health · 2025Article
- Mental health challenges and HIV status disclosure among children and adolescents living with HIV in Eastern Uganda.Scientific reports · 2025Article
- Family Support and Depression among Adolescents Living with HIV in Northern Nigeria.Current HIV research · 2025Article
- Article
- The effect of multi-level HIV prevention interventions on common mental disorders among adolescents and young adults in rural South Africa.PLOS global public health · 2025Article
- Article
- Prevalence of depressive symptoms in adolescents living with HIV in Johannesburg, South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2024Article
- Depressive Symptoms and Associated Factors Among People Living with HIV/AIDS and Undergoing Antiretroviral Therapy: A Cross-Sectional Study in the Amathole District, South Africa.Journal of multidisciplinary healthcare · 2023Article
- Stigma and mental health challenges among adolescents living with HIV in selected adolescent-specific antiretroviral therapy clinics in Zomba District, Malawi.BMC pediatrics · 2022Article
- Prevalence and related factors of depressive symptoms among HIV/AIDS in Ningbo, China: A cross-sectional study.Frontiers in psychiatry · 2022Article
- Prevalence, Risk Factors, and Negative Outcomes of Anxiety and Depressive Disorders among HIV-Infected Children and Adolescents in Uganda: CHAKA Study 2014-2017.Psychiatry journal · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren and adolescents continue to have HIV/AIDS in southern Saharan Africa. Scaling up of HIV services has significantly improved access to ARV and consequently improved on morbidity and mortality related to HIV/AIDS including opportunistic infection. Despite the above efforts, non-communicable conditions including mental disorders such as depression have been observed to contribute to the burden of disabilities about which little is documented. This study, therefore, aimed to determine the magnitude of depressive symptoms and the associated factors among HIV-infected children and adolescents.
methodsThe study was a matched case-control design involving 300 cases of HIV-infected children matched by age and sex against 600 uninfected controls. Systematic sampling technique was used to select the cases while multistage sampling technique was employed to identify villages/ streets purposive and sampling technique was employed to obtain participants from households.
resultsThe overall prevalence of depressive symptoms among the cohort of 900 participants was found to be 12.9%, with 27% of HIV-infected and 5.8% of HIV-uninfected children and adolescents screened positive for depressive symptoms. Multiple logistic regression revealed that being HIV-infected (AOR 1.96(1.11-3.45)), residing in a rural setting (AOR 0.61(0.39-0.96)) and history of childhood deprivation (AOR 4.76 (2.79-8.13)) were significantly associated with depressive symptoms.
conclusionHIV infected adolescents are more affected by depression compared to non-infected counterparts. Childhood deprivation was significantly associated with presence of depressive symptoms. Integration of mental health evaluation and treatment into the HIV care provided for adolescents can be beneficial. More studies to delineate factors associated with depressed adolescents with HIV may add value to the body of knowledge and overall improvement of care.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.