Trial reportPloS one2018
Chronic Obstructive Pulmonary Disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort.
Trial report in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Clinical Value of Nutritional Assessment Tools in Older Adults with Chronic Obstructive Pulmonary Disease: An Integrative Review.Clinical interventions in aging · 2025Pooled it
- Modifiable risk factors that may be addressed in routine care to prevent progression to and extension of multimorbidity in people with COPD: a systematic literature review.BMJ open respiratory research · 2024Pooled it
- Assessment of comorbidities and prognosis in patients with COPD diagnosed with the fixed ratio and the lower limit of normal: a systematic review and meta-analysis.Respiratory research · 2020Pooled it
- Association between P-pulmonale and respiratory morbidity in COPD: a secondary analysis of the BLOCK-COPD trial.BMC pulmonary medicine · 2023Trial
- Chronic obstructive pulmonary disease in severe mental illness: A timely diagnosis to advance the process of quitting smoking.European psychiatry : the journal of the Association of European Psychiatrists · 2021Trial
- Social connection and living with severe chronic obstructive pulmonary disease: A qualitative analysis.Journal of health psychology · 2026Article
- Fueling the fire: metabolic dysfunction and senescence as drivers of lung aging and disease.Physiological reviews · 2026Review
- Bidirectional Clinical Interactions among Exacerbations and Comorbidities in COPD: A Narrative Review.Seminars in respiratory and critical care medicine · 2026Review
- Cardiovascular components of the COTE index predict acute exacerbations and healthcare costs in patients with chronic obstructive pulmonary disease: a nationwide linked cohort study.Respiratory research · 2026Article
- Severe Obesity and Alpha-1 Antitrypsin Deficiency-Associated COPD: A Dual Burden on Health and Quality of Life.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026Article
- The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations.BMC medicine · 2026Article
- Risk factors for COPD exacerbations and mortality, and variation between primary care settings: the PRAXIS cohort study in Sweden.Family medicine and community health · 2026Article
- Chronic Obstructive Pulmonary Disease and Multimorbidity: Insights from a National Claims Administrative Database.International journal of chronic obstructive pulmonary disease · 2026Article
- Impact of a follow-up visit on two-year mortality after severe exacerbation of COPD in Finland.European clinical respiratory journal · 2026Article
- Low Lung Function in Middle-Aged Smokers Impacts Health Status, Morbidities, and Mortality: An Observational Analysis of the Lovelace Smokers Cohort.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Advanced machine learning models for prediction of readmission and mortality risks in patients with chronic obstructive pulmonary disease using routine clinical data.Fujita medical journal · 2025Article
- Disease network analysis to reveal comorbidity patterns in hospitalized patients with COPD using large-scale administrative health data.Scientific reports · 2025Article
- Article
- Patterns of symptom deterioration can support multimorbidity management in COPD: Perspectives of patients and healthcare professionals.PloS one · 2025Article
- Comorbidities and Cause of Death in COPD Patients Compared to Non-COPD Controls: An 8-year Observational Retrospective Healthcare Claims Database Cohort Study.International journal of chronic obstructive pulmonary disease · 2025Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAging is an important risk factor for most chronic diseases. Patients with COPD develop more comorbidities than non-COPD subjects. We hypothesized that the development of comorbidities characteristically affecting the elderly occur at an earlier age in subjects with the diagnosis of COPD. METHODS AND
findingsWe included all subjects carrying the diagnosis of COPD (n = 27,617), and a similar number of age and sex matched individuals without the diagnosis, extracted from the 727,241 records of individuals 40 years and older included in the EpiChron Cohort (Aragon, Spain). We compared the cumulative number of comorbidities, their prevalence and the mortality risk between both groups. Using network analysis, we explored the connectivity between comorbidities and the most influential comorbidities in both groups. We divided the groups into 5 incremental age categories and compared their comorbidity networks. We then selected those comorbidities known to affect primarily the elderly and compared their prevalence across the 5 age groups. In addition, we replicated the analysis in the smokers' subgroup to correct for the confounding effect of cigarette smoking. Subjects with COPD had more comorbidities and died at a younger age compared to controls. Comparison of both cohorts across 5 incremental age groups showed that the number of comorbidities, the prevalence of diseases characteristic of aging and network's density for the COPD group aged 56-65 were similar to those of non-COPD 15 to 20 years older. The findings persisted after adjusting for smoking.
conclusionMultimorbidity increases with age but in patients carrying the diagnosis of COPD, these comorbidities are seen at an earlier age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.