Evidence map›Paper›PMID 29470438›Full record

ArticleInternational journal of molecular sciences2018

Altered Expression of Ganglioside Metabolizing Enzymes Results in GM3 Ganglioside Accumulation in Cerebellar Cells of a Mouse Model of Juvenile Neuronal Ceroid Lipofuscinosis.

Aleksandra Somogyi, Anton Petcherski, Benedikt Beckert, Mylene Huebecker, David A Priestman, Antje Banning, Susan L Cotman, Frances M Platt, Mika O Ruonala, Ritva Tikkanen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Aleksandra SomogyiCenter for Membrane Proteomics, Goethe University of Frankfurt, 60438 Frankfurt am Main, Germany. aleksandra.somogyi@ucc.ie.
Anton PetcherskiCenter for Membrane Proteomics, Goethe University of Frankfurt, 60438 Frankfurt am Main, Germany. apetcherski@mednet.ucla.edu.
Benedikt BeckertInstitute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35292 Giessen, Germany. Benedikt.Beckert@biochemie.med.uni-giessen.de.
Mylene HuebeckerDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. mylene.huebecker@pharm.ox.ac.uk.
David A PriestmanDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. david.priestman@pharm.ox.ac.uk.
Antje BanningInstitute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35292 Giessen, Germany. Antje.banning@biochemie.med.uni-giessen.de.
Susan L CotmanCenter for Genomic Medicine, Department of Neurology, Massachusetts General Hospital Research Institute, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA. cotman@helix.mgh.harvard.edu.
Frances M PlattDepartment of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK. frances.platt@pharm.ox.ac.uk.
Mika O RuonalaCenter for Membrane Proteomics, Goethe University of Frankfurt, 60438 Frankfurt am Main, Germany. mika@icit.bio.
Ritva TikkanenInstitute of Biochemistry, Medical Faculty, University of Giessen, Friedrichstrasse 24, 35292 Giessen, Germany. Ritva.Tikkanen@biochemie.med.uni-giessen.de.ORCID 0000-0002-8393-1825
Goethe University Frankfurt · DEJustus-Liebig-Universität Gießen · DEUniversity of Oxford · GBHarvard University · US

Funding

Endocytosis in JNCLR01NS073813 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI COTMAN, SUSAN LYNN · 2011 to 2015
$1.8M
NINDS NIH HHS R01 NS073813Wellcome Trust
6 · The paper itself

Abstract

Juvenile neuronal ceroid lipofuscinosis (JNCL) is caused by mutations in the

Indexed as

AnimalsCerebellumCholera ToxinDisease Models, AnimalG(M3) GangliosideLysosomesMembrane GlycoproteinsMiceMolecular ChaperonesNeuronal Ceroid-LipofuscinosesCholera ToxinCLN3 protein, mouseG(M3) GangliosideMembrane GlycoproteinsMolecular ChaperonesBatten diseaseCLN3gangliosidesglycosphingolipidslysosomal storage disordersneuronal ceroid lipofuscinosis

Identifiers

PMID29470438
PMCPMC5855847
OpenAlexW2793854725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.