Evidence map›Paper›PMID 29469806›Full record

ArticleeLife2018

MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis.

Saman Hussain, Carl N Wivagg, Piotr Szwedziak, Felix Wong, Kaitlin Schaefer, Thierry Izoré, Lars D Renner, Matthew J Holmes, Yingjie Sun, Alexandre W Bisson-Filho and 4 more

Abstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed.

  1. A lipid cue drives the subcellular localization of a self-inserting bacterial transmembrane protein.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  5. Article
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  8. Sensing the shape of a surface by tightly surface-bound filaments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Conformational regulation of two essential activators of bacterial cell elongation.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Mechanics ofMolecular biology of the cell · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Molecular biology of the cell · 2025
    Article
  16. Review
  17. Article
  18. Halofilins as emerging bactofilin families of archaeal cell shape plasticity orchestrators.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article

55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Saman Hussain *Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Carl N Wivagg *Department of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Piotr SzwedziakMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0002-5766-0873
Felix WongHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, United States.ORCID http://orcid.org/0000-0002-2309-8835
Kaitlin SchaeferDepartment of Microbiology and Immunology, Harvard University, Cambridge, United States.
Thierry IzoréMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.
Lars D RennerLeibniz Institute of Polymer Research, Dresden, Germany.
Matthew J HolmesDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Yingjie SunDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Alexandre W Bisson-FilhoDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.
Suzanne WalkerDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, United States.
Ariel AmirHarvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, United States.ORCID http://orcid.org/0000-0003-2611-0139
Jan LöweMRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0002-5218-6615
Ethan C GarnerDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, United States.ORCID http://orcid.org/0000-0003-0141-3555

Funding

Mechanism and Inhibition of Enzymes that Assemble Bacterial Cell WallR01GM076710 · NIGMS · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2007 to 2019
$5.9M
Dissecting bacterial cell wall synthesis using in vivo single molecule trackingDP2AI117923 · NIAID · HARVARD UNIVERSITY · PI GARNER, ETHAN CLARK · 2014 to 2014
$2.3M
Howard Hughes Medical Institute International Student Research FellowMedical Research Council MC_U105184326Medical Research Council U105184326NIAID NIH HHS DP2 AI117923NIAID NIH HHS DP2AI117923-01NIGMS NIH HHS R01 GM076710Wellcome TrustWellcome Trust 095514/Z/11/Z
6 · The paper itself

Abstract

MreB is essential for rod shape in many bacteria. Membrane-associated MreB filaments move around the rod circumference, helping to insert cell wall in the radial direction to reinforce rod shape. To understand how oriented MreB motion arises, we altered the shape of

Indexed as

Bacillus subtilisBacterial ProteinsCell MembraneCell WallPeptidoglycanProtein TransportBacterial ProteinsPeptidoglycanactinBacillus subtilisB. subtiliscell shapecell wallE. coliinfectious diseasemicrobiologypeptidoglycanself organization

Identifiers

PMID29469806
PMCPMC5854468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.