Evidence map›Paper›PMID 29468901›Full record

SynthesisCartilage2019

Osteochondritis Dissecans of the Knee - Conservative Treatment Strategies: A Systematic Review.

Luca Andriolo, Christian Candrian, Tiziana Papio, Alessia Cavicchioli, Francesco Perdisa, Giuseppe Filardo

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05332288 (Triphasic Osteochondral Scaffold for the Treatment of Osteochondritis Dissecans of the Knee), which is not on this map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05332288 recruitingnot on this mapstarted 2022, after this paper: background citation

Triphasic Osteochondral Scaffold for the Treatment of Osteochondritis Dissecans of the Knee: Observational Study

TypeobservationalSponsorIstituto Ortopedico RizzoliRan2022 to 2029Enrolled30ConditionsOsteochondritis Dissecans Knee
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Pooled it
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  19. Efficacy of the pridie drilling technique in knee osteochondritis dissecans among children and young adults: follow-up of 41 cases.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
    Article
  20. Top 50 Most-Cited Studies about Osteochondritis Dissecans.Arthroscopy, sports medicine, and rehabilitation · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Luca Andriolo1 IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.
Christian Candrian2 Ospedale Regionale di Lugano Civico e Italiano, Lugano, Ticino, Switzerland.
Tiziana Papio1 IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.
Alessia Cavicchioli1 IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.
Francesco Perdisa1 IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.
Giuseppe Filardo1 IRCCS Rizzoli Orthopaedic Institute, Bologna, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Ortopedico Rizzoli · ITOspedale regionale di Lugano · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOsteochondritis dissecans (OCD) lesions are a relevant problem that affects the long-term prognosis of young patients. The purpose of this study was to analyze the evidence on potential and indications of nonsurgical treatment strategies for knee OCD.

designThe search was conducted on 3 medical electronic databases according to PRISMA guidelines, including reports of any level of evidence dealing with the conservative management of knee OCD. Of 1688 identified records, 55 full-text articles were screened: 27 studies met the inclusion criteria, for a total of 908 knees, and were used for the analysis.

resultsNo high-level studies were found: 24 articles were case series and 3 case reports, reporting on different treatments summarized in (1) restriction of physical activity, (2) physiokinesitherapy and muscle-strengthening exercises, (3) physical instrumental therapies, (4) limitation of weightbearing, and (5) immobilization. The analysis showed an overall healing rate of 61.4%, with large variability (10.4%-95.8%). A conservative treatment based on restriction of sport and strenuous activities seems a favorable approach, possibly combined with physiokinesitherapy. Negative prognostic factors were also identified: larger lesion size, more severe lesion stages, older age and skeletal maturity, discoid meniscus, and clinical presentation with swelling or locking.

conclusionsThe literature on conservative treatments for knee OCD is scarce. Among different non-surgical treatment options, strenuous activity restriction seems a favorable approach, whereas there is no evidence that physical instrumental therapy, immobilization, or weightbearing limitation could be beneficial. However, further studies are needed to improve treatment potential and indications for the conservative management of knee OCD.

Indexed as

AdolescentCartilageChildChild, PreschoolConservative TreatmentExerciseFemaleHumansKnee JointMaleOsteochondritis DissecansOutcome Assessment, Health CarePhysical Therapy ModalitiesPrevalencePrognosisResistance Trainingcartilageconservative treatmentkneeosteochondralosteochondritis dissecans

Identifiers

PMID29468901
PMCPMC6585290
OpenAlexW2792640464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.