ArticleHuman brain mapping2018
Explaining the heterogeneity of functional connectivity findings in multiple sclerosis: An empirically informed modeling study.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Neurophysiological brain function predicts response to cognitive rehabilitation and mindfulness in multiple sclerosis: a randomized trial.Journal of neurology · 2024Trial
- Employing Connectome-Based Models to Predict Working Memory in Multiple Sclerosis.Brain connectivity · 2022Trial
- Functional connectivity changes are associated with disability progression in multiple sclerosis: a longitudinal fMRI study.Journal of neurology · 2025Article
- Neurophysiological MEG markers of cognitive impairment and performance validity in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Abnormal thalamic functional connectivity correlates with cardiorespiratory fitness and physical activity in progressive multiple sclerosis.Journal of neurology · 2023Article
- Altered neural intrinsic oscillations in patients with multiple sclerosis: effects of cortical thickness.Frontiers in neurology · 2023Article
- Comparing individual and group-level simulated neurophysiological brain connectivity using the Jansen and Rit neural mass model.Network neuroscience (Cambridge, Mass.) · 2023Article
- Seizures and multiple sclerosis‑more than an epidemiological association (Review).Experimental and therapeutic medicine · 2022Review
- Inhibitory synaptic loss drives network changes in multiple sclerosis: An ex vivo to in silico translational study.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022Article
- The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics.NeuroImage. Clinical · 2022Review
- Article
- Longitudinal Network Changes and Conversion to Cognitive Impairment in Multiple Sclerosis.Neurology · 2021Article
- Increased functional sensorimotor network efficiency relates to disability in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2021Article
- Article
- Mind the gap: from neurons to networks to outcomes in multiple sclerosis.Nature reviews. Neurology · 2021Review
- Brain dysconnectivity relates to disability and cognitive impairment in multiple sclerosis.Human brain mapping · 2021Article
- Alterations in functional connectivity are associated with white matter lesions and information processing efficiency in multiple sclerosis.Brain imaging and behavior · 2021Article
- Article
- Uncertainty in Functional Network Representations of Brain Activity of Alcoholic Patients.Brain topography · 2021Article
- Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
To understand the heterogeneity of functional connectivity results reported in the literature, we analyzed the separate effects of grey and white matter damage on functional connectivity and networks in multiple sclerosis. For this, we employed a biophysical thalamo-cortical model consisting of interconnected cortical and thalamic neuronal populations, informed and amended by empirical diffusion MRI tractography data, to simulate functional data that mimic neurophysiological signals. Grey matter degeneration was simulated by decreasing within population connections and white matter degeneration by lowering between population connections, based on lesion predilection sites in multiple sclerosis. For all simulations, functional connectivity and functional network organization are quantified by phase synchronization and network integration, respectively. Modeling results showed that both cortical and thalamic grey matter damage induced a global increase in functional connectivity, whereas white matter damage induced an initially increased connectivity followed by a global decrease. Both white and especially grey matter damage, however, induced a decrease in network integration. These empirically informed simulations show that specific topology and timing of structural damage are nontrivial aspects in explaining functional abnormalities in MS. Insufficient attention to these aspects likely explains contradictory findings in multiple sclerosis functional imaging studies so far.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.