Evidence map›Paper›PMID 29468672›Full record

ArticleEpilepsia2018

Ca

Stuart M Cain, John R Tyson, Hyun-Beom Choi, Rebecca Ko, Paulo J C Lin, Jeffrey M LeDue, Kim L Powell, Louis-Philippe Bernier, Ravi L Rungta, Yi Yang and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Epilepsia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 56 citations in OpenAlex.

  1. Pacemaking in the lymphatic system.The Journal of physiology · 2026
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  4. Activation of GABA transmission by clonazepam reverses the autistic-like phenotypes of the Cav3.2 knockout mice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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  8. Article
  9. Article
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  11. State-Dependent Blockade of Dorsal Root Ganglion Voltage-Gated NaInternational journal of molecular sciences · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. [Mibefradil improves skeletal muscle mass, function and structure in obese mice].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Stuart M CainMichael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
John R TysonMichael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Hyun-Beom ChoiDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Rebecca KoDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Paulo J C LinLife Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Jeffrey M LeDueDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Kim L PowellThe Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Louis-Philippe BernierDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Ravi L RungtaDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Yi YangMichael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Pieter R CullisLife Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
Terence J O'BrienThe Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Brian A MacVicarDjavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
Terrance P SnutchMichael Smith Laboratories and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.
University of British Columbia · CAVancouver Coastal Health · CAMichael Smith Health Research BC · CAMonash University · AU

Funding

CIHR 10677CIHR 115121CIHR 148397CIHR 8545CIHR FRN148469CIHR TCE‐117869
6 · The paper itself

Abstract

objectiveGenetic alterations have been identified in the CACNA1H gene, encoding the Ca

methodsPathophysiological contributions of Ca

resultsTRN neurons from GAERS display sustained oscillatory burst-firing that is both age- and frequency-dependent, occurring only in the frequencies overlapping with GAERS SWDs and correlating with the expression of a Ca SIGNIFICANCE: This supports a role for TRN Ca

Indexed as

Action PotentialsAnimalsCalcium Channels, T-TypeElectroencephalographyEpilepsy, AbsenceFemaleMaleNeuronsRatsRats, TransgenicSeizuresThalamusCacna1h protein, ratCalcium Channels, T-Typeabsence epilepsylow threshold spikethalamocorticalT-type calcium channel

Identifiers

PMID29468672
PMCPMC5900875
OpenAlexW2789553480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.