Evidence map›Paper›PMID 29468562›Full record

ArticleMolecular neurobiology2018

PKCδ Knockout Mice Are Protected from Dextromethorphan-Induced Serotonergic Behaviors in Mice: Involvements of Downregulation of 5-HT

Hai-Quyen Tran, Youngho Lee, Eun-Joo Shin, Choon-Gon Jang, Ji Hoon Jeong, Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima, Hyoung-Chun Kim

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Guanosine ameliorates positive symptoms of schizophreniaAmerican journal of translational research · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Hai-Quyen TranNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
Youngho LeeNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea.
Eun-Joo ShinNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea. shinej@kangwon.ac.kr.
Choon-Gon JangDepartment of Pharmacology, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Ji Hoon JeongDepartment of Pharmacology, College of Medicine, Chung-Ang University, Seoul, 06974, Republic of Korea.
Akihiro MouriAdvanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Toyoake, Aichi, 470-1192, Japan.
Kuniaki SaitoAdvanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Toyoake, Aichi, 470-1192, Japan.
Toshitaka NabeshimaAdvanced Diagnostic System Research Laboratory, Fujita Health University Graduate School of Health Science, Toyoake, Aichi, 470-1192, Japan.
Hyoung-Chun KimNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, 24341, Republic of Korea. kimhc@kangwon.ac.kr.ORCID http://orcid.org/0000-0003-0420-795X
Kangwon National University · KRFujita Health University · JPChung-Ang University · KRSungkyunkwan University · KR

Funding

Japan Society for the Promotion of Science 17H04252Korea Food and Drug Administration, Republic of Korea 14182MFDS979National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT, Republic of Korea, (#NRF-2017R1A2B1003346 and #NRF-2016R1A1A1A05005201
6 · The paper itself

Abstract

We investigated whether a specific serotonin (5-HT) receptor-mediated mechanism was involved in dextromethorphan (DM)-induced serotonergic behaviors. We firstly observed that the activation of 5-HT

Indexed as

Behavior, AnimalDown-RegulationUp-RegulationAcetophenonesAnimalsBenzopyransCell NucleusDextromethorphanGlutamate-Cysteine LigaseGlutathioneGlutathione DisulfideHypothalamusHypothermia, InducedIsoenzymesMice, Inbred C57BLMice, KnockoutAcetophenonesBenzopyransDextromethorphanGlutamate-Cysteine LigaseGlutathioneGlutathione DisulfideIsoenzymesN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideNeuroprotective AgentsNF-E2-Related Factor 2PiperazinesProtein Kinase C-deltaPyridinesReceptor, Serotonin, 5-HT1AReceptor, Serotonin, 5-HT2ARNA, MessengerrottlerinSerotoninSerotonin 5-HT1 Receptor Antagonists5-HT1A receptorDextromethorphanHypothalamusNuclear factor erythroid-2-related factor 2Protein kinase C δ knockout miceSerotonin syndrome

Identifiers

PMID29468562
OpenAlexW2792191438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.