ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2018
What Is the Minimum Number of Examined Lymph Nodes After Neoadjuvant Therapy in Rectal Cancer?
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Validation of Lymph Node Thresholds as Prognostic Factors in Medullary Thyroid Cancer Staging.Annals of surgical oncology · 2026Article
- Log odds of positive lymph nodes-based staging system for colorectal cancer patients with inadequate lymph nodes harvested: a potential reference for adjuvant chemotherapy.Journal of gastrointestinal oncology · 2025Article
- Robotic Rectal Resection for Rectal Cancer in Elderly Patients: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Examined lymph node numbers influence prognosis in rectal cancer treated with neoadjuvant therapy.Cancer pathogenesis and therapy · 2023Article
- Lymph Node Ratio Improves Prediction of Overall Survival in Esophageal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy: A National Cancer Database Analysis.Annals of surgery · 2023Article
- A Preoperative Scoring System to Predict the Risk of Inadequate Lymph Node Count in Rectal Cancer.Frontiers in oncology · 2022Article
- Effects of neoadjuvant chemotherapy plus chemoradiotherapy on lymph nodes in rectal adenocarcinoma.Virchows Archiv : an international journal of pathology · 2021Article
- A retrospective study on the impact of the number of resected lymph nodes on the survival outcome of stage IV rectal cancer patients after preoperative therapy.Journal of gastrointestinal oncology · 2020Article
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Authors and funding
8 authors.
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Abstract
backgroundTo date, no guidelines have standardized the number of examined lymph nodes (eLNs) after neoadjuvant treatment. This study investigated the minimum number of eLNs required for patients with rectal cancer (RC) who received neoadjuvant treatment. MATERIAL AND
methodsThis study was based on data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked database. We included 2173 patients with RC who received neoadjuvant therapy. Restricted cubic spline was used to analyze the association between eLNs and lymph node metastasis (LNM).
resultsThe number of eLNs was an independent predictive factor for the presence of LNM (odds ratio 1.033; 95% confidence interval 1.020-1.046; P < 0.001). When the number of eLN ≤ 16, 10 and 11 eLNs had the highest rates of positive LNM. Analysis of the restricted cubic spline method found that when number of eLNs was < 10, the LNM rate increased rapidly, but this increase was not so obviously when there were > 10 eLNs.
conclusionsAmong RC patients who receive neoadjuvant therapy, the minimum number of eLNs may be 10 to ensure pathological quality.
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