SynthesisCurrent heart failure reports2018
Right Ventricular Dysfunction and Its Contribution to Morbidity and Mortality in Left Ventricular Heart Failure.
Synthesis in Current heart failure reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Anesthetic protocol for right ventricular dysfunction management in heart transplantation: systematic review, development and validation.BMC anesthesiology · 2021Pooled it
- Association Between Coronary Artery Calcium Score and Right Ventricular Dysfunction: Insights from Combined Echocardiographic and CT Assessment.Journal of clinical medicine · 2026Article
- Prognostic value of the TAPSE/PASP-ratio in patients with severe mitral regurgitation undergoing transcatheter edge-to-edge mitral valve repair.BMC cardiovascular disorders · 2026Article
- Withaferin A Attenuates Angiotensin II-Induced Right Ventricular Dysfunction and Fibrosis.International journal of molecular sciences · 2026Article
- Right Ventricular-Pulmonary Artery Coupling Predicts Early Myocardial Strain Improvement in SGLT2 Inhibitor-Treated HFrEF.Journal of the Saudi Heart Association · 2026Article
- Therapeutic potential of Withaferin A in cancer-induced muscle and cardiac wasting.Journal of ovarian research · 2025Review
- Effect of Iron Deficiency on Right Ventricular Strain in Patients Diagnosed with Acute Heart Failure.Journal of clinical medicine · 2025Article
- Right Atrial Pressure/Pulmonary Capillary Wedge Pressure Ratio Predicts In-Hospital Mortality in Left Ventricular Assist Device Recipients.Journal of clinical medicine · 2025Article
- Transcriptional Signatures of the Right Ventricle in End-Stage Heart Failure.Pulmonary circulation · 2025Article
- Characteristics, Treatment, and Prognosis of Heart Failure Patients with Chronic Obstructive Pulmonary Disease in the Colombian Heart Failure Registry (RECOLFACA).Journal of cardiovascular development and disease · 2024Article
- Early Alteration of Right Ventricle-Pulmonary Artery Coupling in Experimental Heart Failure With Preserved Ejection Fraction.Journal of the American Heart Association · 2024Article
- Perioperative management of the vulnerable and failing right ventricle.Perioperative medicine (London, England) · 2024Review
- Right ventricular cardiomyocyte expansion accompanies cardiac regeneration in newborn mice after large left ventricular infarcts.JCI insight · 2024Article
- Clinical predictors of right ventricular dysfunction and association with adverse outcomes in peripartum cardiomyopathy.ESC heart failure · 2024Article
- Right atrial structural remodeling predict worse outcomes in transcatheter mitral valve repair.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2023Article
- The right ventricular involvement in dilated cardiomyopathy: prevalence and prognostic implications of the often-neglected child.Heart failure reviews · 2022Review
- Revival and Revision of Right Ventricular Assessment by Machine Learning.JACC. Cardiovascular imaging · 2022Article
- Exercise right ventricular ejection fraction predicts right ventricular contractile reserve.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- The right ventricular transcriptome signature in Ossabaw swine with cardiometabolic heart failure: implications for the coronary vasculature.Physiological genomics · 2021Article
- Mechanics of right ventricular dysfunction in pulmonary arterial hypertension and heart failure with preserved ejection fraction.Cardiovascular diagnosis and therapy · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn patients with left-sided HF, there has been less emphasis on the pathophysiology of the RV in terms of diagnostic evaluation and treatment, versus focus on structural abnormalities of the LV. This review seeks to delineate the importance of RV dysfunction in terms of its contribution to symptomatic limitations and cardiovascular outcomes in patients with left-sided HF. RECENT
findingsRecent studies have demonstrated that RV dysfunction is common in both HFpEF and HFrEF, but more pronounced in HFrEF. LV dysfunction and atrial fibrillation are most commonly associated with RV dysfunction in left-sided HF. RV dysfunction may develop due to afterload-dependent and afterload-independent pathways. Regardless, RV dysfunction is strongly associated with functional limitations and worsened survival in patients with left-sided HF. In patients with HFpEF, a recent study showed that RV failure was the most common cause of overall mortality. Among LVAD patients and patients post-cardiac transplantation, RV dysfunction is also strongly associated with survival. Despite a number of previous and ongoing clinical trials that target the RV directly or decrease RV afterload in left-sided HF, there are no definitive therapies specifically targeting RV dysfunction in left-sided HF patients
conclusionsRV dysfunction is an important determinant of symptomatic limitations and cardiovascular outcomes in patients with left-sided HF. Further research is needed to developed pharmacotherapy that may target the RV specifically in left-sided HF patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.