Evidence map›Paper›PMID 29468461›Full record

ArticleEuropean journal of nutrition2019

Flavonoid intake from fruit and vegetables during adolescence is prospectively associated with a favourable risk factor profile for type 2 diabetes in early adulthood.

Katharina J Penczynski, Christian Herder, Danika Krupp, Johanna Rienks, Sarah Egert, Stefan A Wudy, Michael Roden, Thomas Remer, Anette E Buyken

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Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 41 citations in OpenAlex.

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  17. Current developments in nutrition · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Katharina J PenczynskiDONALD Study Dortmund, Department of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Heinstück 11, 44225, Dortmund, Germany.
Christian HerderInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
Danika KruppDONALD Study Dortmund, Department of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Heinstück 11, 44225, Dortmund, Germany.
Johanna RienksDepartment of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Endenicher Allee 11-13, 53115, Bonn, Germany.
Sarah EgertDepartment of Nutrition and Food Sciences (IEL), Nutritional Physiology, University of Bonn, Nußallee 9, 53115, Bonn, Germany.
Stefan A WudyPediatric Endocrinology and Diabetology, Laboratory for Translational Hormone Analytics, Peptide Hormone Research Unit, Center of Child and Adolescent Medicine, Justus Liebig University, Feulgenstrasse 12, 35392, Gießen, Germany.
Michael RodenInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University Düsseldorf, Auf'm Hennekamp 65, 40225, Düsseldorf, Germany.
Thomas RemerDONALD Study Dortmund, Department of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Heinstück 11, 44225, Dortmund, Germany.
Anette E BuykenDONALD Study Dortmund, Department of Nutrition and Food Sciences (IEL), Nutritional Epidemiology, University of Bonn, Heinstück 11, 44225, Dortmund, Germany. anette.buyken@uni-paderborn.de.
University of Bonn · DEHeinrich Heine University Düsseldorf · DEJustus-Liebig-Universität Gießen · DEPaderborn University · DE

Funding

German Federal Ministry of Food, Agriculture and Consumer Protection 2810HS035World Cancer Research Fund (NL) 2010/248World Cancer Research Fund (NL) 2013/975
6 · The paper itself

Abstract

purposeFlavonoid consumption during adolescence could contribute to preventing adult onset of type 2 diabetes mellitus. We investigated the prospective association between habitual intake of flavonoids from fruit and vegetables (FlavFV) during adolescence and risk markers of type 2 diabetes in early adulthood.

methodsThis analysis included participants of the DONALD Study, who had provided a fasting blood sample in adulthood (18-39 years), data on FlavFV-intake during adolescence (females: 9-15 years, males: 10-16 years) and relevant covariates. Habitual FlavFV-intake was either estimated using repeated 3-day weighed dietary records (n = 268), or the validated biomarker hippuric acid (uHA)-excretion in repeated 24-h urine samples (n = 241). Multivariable linear regressions were performed to analyse the prospective associations of FlavFV or uHA with homeostasis model assessment insulin sensitivity (HOMA2-%S), hepatic steatosis index (HSI), fatty liver index (FLI) and a pro-inflammatory score.

resultsHigher FlavFV-intake was independently related to higher HOMA2-%S among females (P

conclusionsOur data indicate that flavonoid consumption from fruit and vegetables during adolescence is associated with a favourable risk factor profile for type 2 diabetes in early adulthood.

Indexed as

Diet RecordsFruitVegetablesAdolescentAdolescent BehaviorAdultAge FactorsBiomarkersChildDiabetes Mellitus, Type 2FemaleFlavonoidsHumansInflammationMaleProspective StudiesBiomarkersFlavonoids24-Hour urinary hippuric acid excretionChronic subclinical inflammationFlavonoids from fruit and vegetablesHomeostasis model assessment of insulin sensitivityIndices of hepatic steatosisProspective

Identifiers

PMID29468461
OpenAlexW2789487733

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.