ArticleAnnals of clinical and translational neurology2018
Seizure semiology: an important clinical clue to the diagnosis of autoimmune epilepsy.
Article in Annals of clinical and translational neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 38 citations in OpenAlex.
- Predicting factors for acute encephalopathy in febrile seizure children with SARS-CoV-2 omicron variant: a retrospective study.BMC pediatrics · 2024Article
- Autoimmune epilepsy, retrospective case series of clinical features, management, and outcomes.Neurosciences (Riyadh, Saudi Arabia) · 2023Article
- The value of immunotherapy in children with initial short-term frequent seizures.Frontiers in neurology · 2022Article
- Autoimmune epilepsy due to N-methyl-D-aspartate receptor antibodies in a child: a case report.Journal of medical case reports · 2021Article
- Recognition of seizure semiology and semiquantitative FDG-PET analysis of anti-LGI1 encephalitis.CNS neuroscience & therapeutics · 2021Article
- Glutamic acid decarboxylase 65-positive autoimmune encephalitis presenting with gelastic seizure, responsive to steroid: A case report.World journal of clinical cases · 2021Article
- Diagnosis and surgical treatment of non-lesional temporal lobe epilepsy with unilateral amygdala enlargement.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Autoimmune Encephalitis in Late-Onset Seizures: When to Suspect and How to Treat.Frontiers in neurology · 2021Article
- Calibration of the Epilepsy Questionnaire for Use in a Low-Resource Setting.Journal of environmental and public health · 2020Article
- HMGB1/CXCL12-Mediated Immunity and Th17 Cells Might Underlie Highly Suspected Autoimmune Epilepsy in Elderly Individuals.Neuropsychiatric disease and treatment · 2020Article
- Relevance of Surface Neuronal Protein Autoantibodies as Biomarkers in Seizure-Associated Disorders.International journal of molecular sciences · 2019Review
- Semi-quantitative FDG-PET Analysis Increases the Sensitivity Compared With Visual Analysis in the Diagnosis of Autoimmune Encephalitis.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The purpose of this study is to analyze the seizure semiologic characteristics of patients with autoimmune epilepsy (AE) and describe the investigation characteristics of AE using a larger sample size. Methods: This observational retrospective case series study was conducted from a tertiary epilepsy center between May 2014 and March 2017. Cases of new-onset seizures were selected based on laboratory evidence of autoimmunity. At the same time, typical mesial temporal lobe epilepsy (MTLE) patients with hippocampal sclerosis (HS) were recruited as the control group from the subjects who underwent presurgical evaluation during the same period. Results: A total of 61 patients with AE were identified. Specific autoimmune antibodies were detected in 39 patients (63.93%), including anti-VGKC in 23 patients (37.70%), anti-NMDA-R in 9 patients (14.75%), anti-GABA Significance: This study highlights important seizure semiologic characteristics of AE. Patients with autoimmune epilepsy had special seizure semiologic characteristics. For patients with autoimmune epilepsy presenting with new-onset seizures in isolation or with a seizure-predominant neurological disorder, the special seizure semiologic characteristics may remind us to test neuronal nuclear/cytoplasmic antibodies early and initiate immunomodulatory therapies as soon as possible. Furthermore, the absence of neural-specific autoantibodies does not rule out AE.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.