ReviewFrontiers in nutrition2018
The Effect of Flaxseed in Breast Cancer: A Literature Review.
Review in Frontiers in nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Phytonutrients and outcomes following breast cancer: a systematic review and meta-analysis of observational studies.JNCI cancer spectrum · 2024Pooled it
- Article
- Widely Targeted Metabolomics Reveals Metabolic Differences Between Yellow and Brown Flaxseed Cultivars (Foods (Basel, Switzerland) · 2026Article
- Nutritional and Health Potential of Edible Seeds: Micronutrient Bioavailability and Mechanistic Insights.Food science & nutrition · 2026Review
- Can flaxseed "milk" prevent anthracycline mediated cardiotoxicity in women with breast cancer (CANFLAX-BC)?Cardio-oncology (London, England) · 2026Article
- Synergistic enzyme action boosts phenolic compounds in flaxseed during germination using a two-level factorial design.Scientific reports · 2025Article
- Screening of maillard reaction substrates from roasted flaxseed and comparative analysis of the antioxidant potential of their products.Food chemistry: X · 2025Article
- Recent advances in nano vehicles encapsulating cinnamic acid and its derivatives as promising anticancer agents.RSC advances · 2025Review
- Flaxseed in Diet: A Comprehensive Look at Pros and Cons.Molecules (Basel, Switzerland) · 2025Review
- Anti-Oxidant and Anti-Cancer Properties of Flaxseed.International journal of molecular sciences · 2025Review
- Clinically proven natural products against breast cancer, with mechanistic insights.Oncology research · 2025Review
- Article
- Gamma rays and sodium azide induced variations in bio-physiological and agronomical traits in linseed (Heliyon · 2024Article
- Health Behavior Change Intervention Preferences Expressed by American Indian Cancer Survivors From a Southwest Tribal Community: Semistructured Interview Study.JMIR formative research · 2024Article
- The Antitumor Effects of α-Linolenic Acid.Journal of personalized medicine · 2024Review
- Nutritional Genomics and Cancer Prevention.Cancer treatment and research · 2024Review
- Article
- Successful Outcome of a Patient with Concomitant Pancreatic and Renal Carcinoma Receiving Secoisolariciresinol Diglucoside Therapy Alone: A Case Report.International medical case reports journal · 2024Article
- Bioactive Compounds for Customized Brain Health: What Are We and Where Should We Be Heading?International journal of environmental research and public health · 2023Review
- Glyoxal-induced disruption of tumor cell progression in breast cancer.Molecular and clinical oncology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is one of the most common cancers and the second most responsible for cancer mortality worldwide. In 2014, in Portugal approximately 27,200 people died of cancer, of which 1,791 were women with breast cancer. Flaxseed has been one of the most studied foods, regarding possible relations to breast cancer, though mainly in experimental studies in animals, yet in few clinical trials. It is rich in omega-3 fatty acids, α-linolenic acid, lignan, and fibers. One of the main components of flaxseed is the lignans, of which 95% are made of the predominant secoisolariciresinol diglucoside (SDG). SDG is converted into enterolactone and enterodiol, both with antiestrogen activity and structurally similar to estrogen; they can bind to cell receptors, decreasing cell growth. Some studies have shown that the intake of omega-3 fatty acids is related to the reduction of breast cancer risk. In animal studies, α-linolenic acids have been shown to be able to suppress growth, size, and proliferation of cancer cells and also to promote breast cancer cell death. Other animal studies found that the intake of flaxseed combined with tamoxifen can reduce tumor size to a greater extent than taking tamoxifen alone. Additionally, some clinical trials showed that flaxseed can have an important role in decreasing breast cancer risk, mainly in postmenopausal women. Further studies are needed, specifically clinical trials that may demonstrate the potential benefits of flaxseed in breast cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.