ArticleMetabolic engineering communications2016
Improving the flux distributions simulated with genome-scale metabolic models of
Article in Metabolic engineering communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Review
- RBI: a novel algorithm for regulatory-metabolic network model in designing the optimal mutant strain.PeerJ. Computer science · 2025Article
- Auxotrophy-based curation improves the consensus genome-scale metabolic model of yeast.Synthetic and systems biotechnology · 2024Article
- The origins of the Guinness stout yeast.Communications biology · 2024Article
- Enzyme-constrained models predict the dynamics of Saccharomyces cerevisiae growth in continuous, batch and fed-batch bioreactors.Microbial biotechnology · 2022Article
- Constraint-based modeling of yeast mitochondria reveals the dynamics of protein import and iron-sulfur cluster biogenesis.iScience · 2021Article
- Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer.Cancers · 2021Article
- Model-guided development of an evolutionarily stable yeast chassis.Molecular systems biology · 2021Article
- A systematic evaluation of Mycobacterium tuberculosis Genome-Scale Metabolic Networks.PLoS computational biology · 2020Article
- EngineeringFrontiers in bioengineering and biotechnology · 2020Article
- Manually curated genome-scale reconstruction of the metabolic network of Bacillus megaterium DSM319.Scientific reports · 2019Article
- Contextualized genome-scale model unveils high-order metabolic effects of the specific growth rate and oxygenation level in recombinantMetabolic engineering communications · 2019Article
- A consensus S. cerevisiae metabolic model Yeast8 and its ecosystem for comprehensively probing cellular metabolism.Nature communications · 2019Article
- Comparison of pathway analysis and constraint-based methods for cell factory design.BMC bioinformatics · 2019Article
- Role of phosphate limitation and pyruvate decarboxylase in rewiring of the metabolic network for increasing flux towards isoprenoid pathway in a TATA binding protein mutant of Saccharomyces cerevisiae.Microbial cell factories · 2018Article
- Mapping the Physiological Response ofFrontiers in microbiology · 2018Article
- Strategies to ImproveIndian journal of microbiology · 2017Review
- Population FBA predicts metabolic phenotypes in yeast.PLoS computational biology · 2017Article
- Improving the phenotype predictions of a yeast genome-scale metabolic model by incorporating enzymatic constraints.Molecular systems biology · 2017Article
- Genome-scale modeling of yeast: chronology, applications and critical perspectives.FEMS yeast research · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-scale metabolic models (GEMs) can be used to evaluate genotype-phenotype relationships and their application to microbial strain engineering is increasing in popularity. Some of the algorithms used to simulate the phenotypes of mutant strains require the determination of a wild-type flux distribution. However, the accuracy of this reference, when calculated with flux balance analysis, has not been studied in detail before. Here, the wild-type simulations of selected GEMs for
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