ArticleMolecular and clinical oncology2018
The multiple faces of Langerhans cell histiocytosis in childhood: A gentle reminder.
Article in Molecular and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Orbital Langerhans Cell Histiocytosis in Young Pediatric Patients: Two Case Reports and Literature Review.Pediatric health, medicine and therapeutics · 2026Article
- Application of pretreatmentAnnals of hematology · 2025Article
- [Clinical analysis of 72 children with Langerhans cell histiocytosis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Oral mucosal lesions with transient self-healing of Langerhans cell histiocytosis: a case report.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2023Article
- Ultrasonographic analysis of Langerhans cell histiocytosis in children: a report of 55 cases.The Journal of international medical research · 2022Article
- Pediatric spontaneous tension pneumothorax in Langerhans cell histiocytosis.Proceedings (Baylor University. Medical Center) · 2020Article
- Childhood Langerhans cell histiocytosis: a disease with many faces.World journal of pediatrics : WJP · 2019Review
- [Langerhans cell histiocytosis involving the oral and maxillofacial region: an analysis of 12 cases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Article
- [Skin biopsy of inflammatory skin diseases in childhood-when is it reasonable?]Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2018Review
- Seborrheic-like dermatitis and liver dysfunction in an infant: signs of Langerhans cell histiocytosis.Anais brasileiros de dermatologiaArticle
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7 authors.
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Abstract
Langerhans cell histiocytosis (LCH) is a rare hematologic disorder that results from the clonal multiplication and accumulation of immature dendritic Langerhans cells. Its reported incidence rate varies, but is considered to be 2.6-8.9 per million children who are <15 years of age each year. It may affect any system or organ. The present study reported 4 pediatric LCH cases in order to highlight the heterogeneity of the initial presentation, and the pitfalls that may mislead clinicians and delay diagnosis. The clinical features, as well as the pathognomonic imaging, pathology findings and treatment options were presented. LCH may be rare, but it should always be included in the differential diagnosis of persistent eczema, unexplained skin lesions, diabetes insipidus and persistent bone pain, among others. While the debate on pathogenesis and treatment is ongoing, high index of suspicion among pediatricians, pediatric oncologists and other specialists (pathologists, dermatologists, orthopaedic surgeons, general practitioners or family physicians) is essential for early diagnosis, and optimal outcome.
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