ArticleWorld journal of emergency surgery : WJES2018
Advanced gallbladder inflammation is a risk factor for gallbladder perforation in patients with acute cholecystitis.
Article in World journal of emergency surgery : WJES, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 43 citations in OpenAlex.
- Gallbladder perforation causing local peritonitis in left upper abdomen: A case report.International journal of surgery case reports · 2025Article
- C-reactive protein and digestive pathologies: A narrative review for daily clinical use.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025Review
- The role of biomarkers in predicting perforated cholecystitis cases: Can the c-reactive protein albumin ratio be a guide?Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Article
- Article
- Delayed laparoscopic cholecystectomy for a patient with coronavirus disease 2019 who developed gangrenous cholecystitis: a case report.Surgical case reports · 2022Article
- Ultrasonographic Evaluation of Gallbladder Diseases: An Original Study.Journal of pharmacy & bioallied sciences · 2022Article
- Value of nonenhanced CT combined with laboratory examinations in the diagnosis of acute suppurative cholecystitis treated with percutaneous cholecystostomy: a retrospective study.BMC gastroenterology · 2022Article
- Complications of cholecystitis: a comprehensive contemporary imaging review.Emergency radiology · 2021Review
- Perforated gallbladder in a parastomal hernia.BMJ case reports · 2021Article
- Occult Perforated Gangrenous Gallbladder Found on Magnetic Resonance Cholangiopancreatography.Cureus · 2021Article
- Concealed gallbladder perforation: a rare case report.Journal of surgical case reports · 2021Article
- Postoperative Outcomes after Index vs Interval Cholecystectomy for Perforated Cholecystitis.Journal of the American College of Surgeons · 2021Article
- Uncommon but valuable for diagnosis: Green deposits on peritoneal fluid cytospins.Clinical case reports · 2021Article
- An Acute General Surgical Unit (AGSU) Negates the Impact of the Tokyo Guidelines 2018 (TG18) Diagnostic Criteria for the Treatment of Acute Cholecystitis.World journal of surgery · 2019Article
- Gallbladder Perforation Secondary to Enteric Fever: An Interesting Case of Acute Abdomen.Cureus · 2019Article
- Peritonitis by perforation of the gall bladder of typhoid origin in children.African journal of paediatric surgery : AJPSArticle
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acute perforated cholecystitis (APC) is probably the most severe benign gallbladder pathology with high rates of morbidity and mortality. The cause of APC has not been fully understood. We postulated that APC is a complication of advanced gallbladder inflammation. The aim of this study was to investigate the extent of gallbladder inflammation in patients with APC. Methods: Patients with intraoperative and histopathologic diagnosis of APC were compared with cases with acute cholecystitis without perforation with respect to the extent of inflammation on histopathology as well as surgical outcomes. Results: Fifty patients with APC were compared to 150 cases without perforation. Advanced age > 65 years and elevated CRP were confirmed on multivariate analysis as independent risk factors for APC. Advanced gallbladder inflammation was seen significantly more often in patients with APC (84.0 vs. 18.7%). Surgery lasted significantly longer 131.3 ± 55.2 min vs. 100.4 ± 47.9 min; the rates of conversion (22 vs. 4%), morbidity (24 vs. 7%), and mortality (8 vs. 1%) were significantly higher in patients with APC. ICU management following surgery was needed significantly more often in the APC group (56 vs. 15%), and the overall length of stay (11.2 ± 12.0 days vs. 5.8 ± 6.5 days) was significantly longer compared to the group without perforation. Conclusion: Acute gallbladder perforation in patients with acute cholecystitis represents the most severe complication of cholecystitis. Acute perforated cholecystitis is a sequela of advanced gallbladder inflammation like empyematous and gangrenous cholecystitis and is associated with poor outcome compared to non-perforated cases.
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