Evidence map›Paper›PMID 29467767›Full record

ArticleFrontiers in immunology2018

Identification of Casz1 as a Regulatory Protein Controlling T Helper Cell Differentiation, Inflammation, and Immunity.

Natarajan Bhaskaran, Zhihui Liu, Senthil S Saravanamuthu, Chunhua Yan, Ying Hu, Lijin Dong, Peggy Zelenka, Lixin Zheng, Vassili Bletsos, Rachel Harris and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. CASZ1 Is Essential for Skin Epidermal Terminal Differentiation.The Journal of investigative dermatology · 2024
    Article
  5. Review
  6. Review
  7. Biomedicines · 2023
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Microbiome Dependent Regulation of TFrontiers in immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Natarajan BhaskaranDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States.
Zhihui LiuCell and Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, United States.
Senthil S SaravanamuthuLaboratory of Molecular and Developmental Biology, National Eye Institute, Bethesda, MD, United States.
Chunhua YanCell and Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, United States.
Ying HuCell and Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, United States.
Lijin DongLaboratory of Molecular and Developmental Biology, National Eye Institute, Bethesda, MD, United States.
Peggy ZelenkaLaboratory of Molecular and Developmental Biology, National Eye Institute, Bethesda, MD, United States.
Lixin ZhengLaboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States.
Vassili BletsosDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States.
Rachel HarrisDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States.
Brenna HarringtonDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States.
Aaron WeinbergDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States.
Carol J ThieleCell and Molecular Biology Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD, United States.
Fengchun YeDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States.
Pushpa PandiyanDepartment of Biological Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, United States.
Case Western Reserve University · USNational Cancer Institute · USNational Eye Institute · USNational Institutes of Health · US

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Alan David Levine · 1994 to 2026
$50.0M
Regulation of Differentiation of Pediatric Embryonal Tumors- NeuroblastomaZIABC010788 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI THIELE, CAROL J · 2009 to 2025
$29.7M
NEI Genetic Engineering CoreZICEY000458 · NEI · NATIONAL EYE INSTITUTE · PI DONG, LIJIN · 2009 to 2025
$22.6M
Vitamin D endocrine system and Protection Against Skin TumorlgenesisP30AR039750 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI COOPER, KEVIN D · 1988 to 2015
$9.1M
NIAID NIH HHS P30 AI036219NIAMS NIH HHS P30 AR039750
6 · The paper itself

Abstract

While T helper (Th) cells play a crucial role in host defense, an imbalance in Th effector subsets due to dysregulation in their differentiation and expansion contribute to inflammatory disorders. Here, we show that Casz1, whose function is previously unknown in CD4

Indexed as

ImmunityAnimalsCD4-Positive T-LymphocytesCell DifferentiationCell LineageChromatin ImmunoprecipitationCytokinesDNA-Binding ProteinsEncephalomyelitis, Autoimmune, ExperimentalGene ExpressionHigh-Throughput Nucleotide SequencingHumansInflammationMiceMice, TransgenicTh17 CellsCASZ1 protein, humanCytokinesDNA-Binding ProteinsTranscription FactorsCD4 differentiationcytokineTh1*Th17T helpertranscriptional regulation

Identifiers

PMID29467767
PMCPMC5808336
OpenAlexW2790488181

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.