ArticleFrontiers in immunology2018
The Macrophage Mannose Receptor Regulate Mannan-Induced Psoriasis, Psoriatic Arthritis, and Rheumatoid Arthritis-Like Disease Models.
Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Immunomodulatory Effects of a Tick Salivary Serpin on Psoriasis-like Inflammation.Life (Basel, Switzerland) · 2026Article
- Exploring the Predictive Value of Gut Microbiome Signatures for Therapy Intensification in Patients With Inflammatory Bowel Disease: A 10-Year Follow-up Study.Inflammatory bowel diseases · 2024Article
- Macrophage Functions in Psoriasis: Lessons from Mouse Models.International journal of molecular sciences · 2024Review
- Mannose-doped metal-organic frameworks induce tumor cell pyroptosis via the PERK pathway.Journal of nanobiotechnology · 2023Article
- The Conundrum of Psoriatic Arthritis: a Pathogenetic and Clinical Pattern at the Midpoint of Autoinflammation and Autoimmunity.Clinical reviews in allergy & immunology · 2023Review
- Challenges and opportunities in animal models of psoriatic arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Discovery of CLEC2B as a diagnostic biomarker and screening of celastrol as a candidate drug for psoriatic arthritis through bioinformatics analysis.Journal of orthopaedic surgery and research · 2023Article
- A New Galactoglucomannan from the Mycelium of the Medicinal Parasitic FungusMolecules (Basel, Switzerland) · 2023Article
- Comparative studies on mannan and imiquimod induced experimental plaque psoriasis inflammation in inbred mice.Clinical and experimental immunology · 2023Article
- Phospholipase A1 Member A Deficiency Alleviates Mannan-Induced Psoriatic Arthritis in Mice Model.International journal of molecular sciences · 2022Article
- The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment.Antioxidants (Basel, Switzerland) · 2022Review
- Variants of beta-glucan polysaccharides downregulate autoimmune inflammation.Communications biology · 2022Article
- Critical role of synovial tissue-resident macrophage niche in joint homeostasis and suppression of chronic inflammation.Science advances · 2021Article
- Differential expression patterns of glycosphingolipids and C-type lectin receptors on immune cells in absence of functional regulatory T cells.Immunity, inflammation and disease · 2020Article
- Mouse CD163 deficiency strongly enhances experimental collagen-induced arthritis.Scientific reports · 2020Article
- Shikimic acid, a mannose bioisostere, promotes hair growth with the induction of anagen hair cycle.Scientific reports · 2019Article
- Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors.Journal of leukocyte biology · 2019Review
- Glucan and Mannan-Two Peas in a Pod.International journal of molecular sciences · 2019Review
- Rapid spread of mannan to the immune system, skin and joints within 6 hours after local exposure.Clinical and experimental immunology · 2019Article
- TanshinoneIIA Alleviates Inflammatory Response and Directs Macrophage Polarization in Lipopolysaccharide-Stimulated RAW264.7 Cells.Inflammation · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The injection of mannan into mice can result in the development of psoriasis (Ps) and psoriatic arthritis (PsA), whereas co-injection with antibodies toward collagen type II leads to a chronic rheumatoid-like arthritis. The critical event in all these diseases is mannan-mediated activation of macrophages, causing more severe disease if the macrophages are deficient in neutrophil cytosolic factor 1 (Ncf1), i.e., lack the capacity to make a reactive oxygen species (ROS) burst. In this study, we investigated the role of one of the receptors binding mannan; the macrophage mannose receptor (MR, CD206). MR is a C-type lectin present on myeloid cells and lymphatics. We found that mice deficient in MR expression had more severe mannan-induced Ps, PsA as well as rheumatoid-like arthritis. Interestingly, the MR-mediated protection was partly lost in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.