Evidence map›Paper›PMID 29467713›Full record

ReviewFrontiers in neurology2018

Potential of Stem Cell-Based Therapy for Ischemic Stroke.

Hany E Marei, A Hasan, R Rizzi, A Althani, N Afifi, C Cenciarelli, Thomas Caceci, Ashfaq Shuaib

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 5 pooled it
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 5 syntheses or guidelines pooled it, 141 citations in OpenAlex.

  1. A review and meta-analysis of stem cell therapies in stroke patients: effectiveness and safety evaluation.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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  13. Emerging Roles of Exosomes in Stroke Therapy.International journal of molecular sciences · 2024
    Review
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  16. Stem cell therapy as a promising approach for ischemic stroke treatment.Current research in pharmacology and drug discovery · 2024
    Review
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 4 countries.

Hany E MareiBiomedical Research Center, Qatar University, Doha, Qatar.
A HasanDepartment of Mechanical and Industrial Engineering, Qatar University, Doha, Qatar.
R RizziInstitute of Cell Biology and Neurobiology (IBCN), Italian National Council of Research (CNR), Rome, Italy.
A AlthaniBiomedical Research Center, Qatar University, Doha, Qatar.
N AfifiQatar Biobank, Doha, Qatar.
C CenciarelliInstitute of Translational Pharmacology (CNR), Roma, Italy.
Thomas CaceciBiomedical Sciences, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA, United States.
Ashfaq ShuaibNeurosciences Institute, Academic Health System, Hamad Medical Corporation, Doha, Qatar.
Qatar University · QACarilion Clinic · USHamad Medical Corporation · QAInstitute of Cell Biology and Neurobiology · ITIstituto di Farmacologia Traslazionale · ITQatar Central Bank · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic stroke is one of the major health problems worldwide. The only FDA approved anti-thrombotic drug for acute ischemic stroke is the tissue plasminogen activator. Several studies have been devoted to assessing the therapeutic potential of different types of stem cells such as neural stem cells (NSCs), mesenchymal stem cells, embryonic stem cells, and human induced pluripotent stem cell-derived NSCs as treatments for ischemic stroke. The results of these studies are intriguing but many of them have presented conflicting results. Additionally, the mechanism(s) by which engrafted stem/progenitor cells exert their actions are to a large extent unknown. In this review, we will provide a synopsis of different preclinical and clinical studies related to the use of stem cell-based stroke therapy, and explore possible beneficial/detrimental outcomes associated with the use of different types of stem cells. Due to limited/short time window implemented in most of the recorded clinical trials about the use of stem cells as potential therapeutic intervention for stroke, further clinical trials evaluating the efficacy of the intervention in a longer time window after cellular engraftments are still needed.

Indexed as

induced pluripotent stem cellsischemic strokemesenchymal stem cellneural stem cellstem cell

Identifiers

PMID29467713
PMCPMC5808289
OpenAlexW2788641685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.