ArticleFrontiers in human neuroscience2018
Closed-Loop Targeted Memory Reactivation during Sleep Improves Spatial Navigation.
Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Promoting memory consolidation during sleep: A meta-analysis of targeted memory reactivation.Psychological bulletin · 2020Pooled it
- The Effect of Closed-Loop Auditory Stimulation on Memory Consolidation and Sleep Physiology in an Ecological Setting.Journal of sleep research · 2026Article
- Modulating sleep: slow oscillation and spindle stimulation effects on physiology and memory.NPJ science of learning · 2026Article
- The effects of targeted reactivation on memories cued once or multiple times during a nap.Neuropsychologia · 2025Article
- Promoting vocabulary learning during sleep at home using closed-loop targeted memory reactivation.Journal of sleep research · 2025Article
- Music-evoked reactivation during continuous perception is associated with enhanced subsequent recall of naturalistic events.bioRxiv : the preprint server for biology · 2025Article
- Unraveling the neurophysiological correlates of phase-specific enhancement of motor memory consolidation via slow-wave closed-loop targeted memory reactivation.Nature communications · 2025Article
- Investigating the impact of the years of blindness on sleep rhythms, dream patterns, and spatial abilities: The BLINDREAM protocol.PloS one · 2025Article
- Selective Modulation of Fear Memory in Non-Rapid Eye Movement Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- An update on recent advances in targeted memory reactivation during sleep.NPJ science of learning · 2024Review
- Respiration modulates sleep oscillations and memory reactivation in humans.Nature communications · 2023Article
- Article
- Targeted dream incubation at sleep onset increases post-sleep creative performance.Scientific reports · 2023Article
- Electrophysiological markers of memory consolidation in the human brain when memories are reactivated during sleep.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Shaping overnight consolidation via slow-oscillation closed-loop targeted memory reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- A Structured Approach to Test the Signal Quality of Electroencephalography Measurements During Use of Head-Mounted Displays for Virtual Reality Applications.Frontiers in neuroscience · 2021Article
- The Intersection of Offline Learning and Rehabilitation.Frontiers in human neuroscience · 2021Article
- Disruption of NREM sleep and sleep-related spatial memory consolidation in mice lacking adult hippocampal neurogenesis.Scientific reports · 2020Article
- Dormio: A targeted dream incubation device.Consciousness and cognition · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sounds associated with newly learned information that are replayed during non-rapid eye movement (NREM) sleep can improve recall in simple tasks. The mechanism for this improvement is presumed to be reactivation of the newly learned memory during sleep when consolidation takes place. We have developed an EEG-based closed-loop system to precisely deliver sensory stimulation at the time of down-state to up-state transitions during NREM sleep. Here, we demonstrate that applying this technology to participants performing a realistic navigation task in virtual reality results in a significant improvement in navigation efficiency after sleep that is accompanied by increases in the spectral power especially in the fast (12-15 Hz) sleep spindle band. Our results show promise for the application of sleep-based interventions to drive improvement in real-world tasks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.