Evidence map›Paper›PMID 29467628›Full record

ArticleFrontiers in neural circuits2018

Anatomical Evidence for a Direct Projection from Purkinje Cells in the Mouse Cerebellar Vermis to Medial Parabrachial Nucleus.

Mitsuhiro Hashimoto, Akihiro Yamanaka, Shigeki Kato, Manabu Tanifuji, Kazuto Kobayashi, Hiroyuki Yaginuma

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neural circuits, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  6. Brain-wide mapping of developmental trajectories of cerebellar efferent projections.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  7. Article
  8. Review
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  12. Characterization of direct Purkinje cell outputs to the brainstem.bioRxiv : the preprint server for biology · 2024
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  13. Article
  14. The cerebellum modulates thirst.Nature neuroscience · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Mitsuhiro HashimotoDepartment of Neuroanatomy and Embryology, Fukushima Medical University Graduate School of Medicine, Fukushima, Japan.
Akihiro YamanakaDepartment of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya-shi, Japan.
Shigeki KatoDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University Graduate School of Medicine, Fukushima, Japan.
Manabu TanifujiLaboratory for Integrative Neural Systems, RIKEN Brain Science Institute, Saitama, Japan.
Kazuto KobayashiDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University Graduate School of Medicine, Fukushima, Japan.
Hiroyuki YaginumaDepartment of Neuroanatomy and Embryology, Fukushima Medical University Graduate School of Medicine, Fukushima, Japan.
Fukushima Medical University · JPNagoya University · JPRIKEN Center for Brain Science · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebellar malformations cause changes to the sleep-wake cycle, resulting in sleep disturbance. However, it is unclear how the cerebellum contributes to the sleep-wake cycle. To examine the neural connections between the cerebellum and the nuclei involved in the sleep-wake cycle, we investigated the axonal projections of Purkinje cells in the mouse posterior vermis by using an adeno-associated virus (AAV) vector (serotype rh10) as an anterograde tracer. When an AAV vector expressing humanized renilla green fluorescent protein was injected into the cerebellar lobule IX, hrGFP and synaptophysin double-positive axonal terminals were observed in the region of medial parabrachial nucleus (MPB). The MPB is involved in the phase transition from rapid eye movement (REM) sleep to Non-REM sleep and

Indexed as

AmidinesAnimalsCerebellar VermisDependovirusGreen Fluorescent ProteinsMaleMice, Inbred ICRNeural PathwaysNeuroanatomical Tract-Tracing TechniquesNeuronal Tract-TracersParabrachial NucleusPurkinje CellsAmidinesdiamidino compound 253-50Green Fluorescent ProteinsNeuronal Tract-Tracersaden-associated virusanterograde tracingcerebellar vermiscerebellum circuitsmedial parabrachial nucleusretrograde tracing

Identifiers

PMID29467628
PMCPMC5808303
OpenAlexW2793501848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.