ArticleFrontiers in neuroscience2018
Understanding the Generation of Network Bursts by Adaptive Oscillatory Neurons.
Article in Frontiers in neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A unified model of short- and long-term plasticity: Effects on network connectivity and information capacity.PLoS computational biology · 2026Article
- Unperturbed dye-based imaging of spontaneous synchronized calcium activity in iPSC-derived neuronal cultures.iScience · 2026Article
- Breaking the burst: Unveiling mechanisms behind fragmented network bursts in patient-derived neurons.Stem cell reports · 2024Article
- Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes.bioRxiv : the preprint server for biology · 2024Article
- Article
- Selective inhibition of excitatory synaptic transmission alters the emergent bursting dynamics ofFrontiers in neural circuits · 2023Article
- Review
- Comparative study between radiofrequency-induced and muscimol-induced inhibition of cultured networks of cortical neuron.PloS one · 2022Article
- Article
- Cytosolic PSD-95 interactor alters functional organization of neural circuits and AMPA receptor signaling independent of PSD-95 binding.Network neuroscience (Cambridge, Mass.) · 2021Article
- Influence of Delayed Conductance on Neuronal Synchronization.Frontiers in physiology · 2020Article
- Influence of Autapses on Synchronization in Neural Networks With Chemical Synapses.Frontiers in systems neuroscience · 2020Article
- Human Motor Neurons With SOD1-G93A Mutation Generated From CRISPR/Cas9 Gene-Edited iPSCs Develop Pathological Features of Amyotrophic Lateral Sclerosis.Frontiers in cellular neuroscience · 2020Article
- Cooperative Phase Adaptation and Amplitude Amplification of Neuronal Activity in the Vagal Complex: An Interplay Between Microcircuits and Macrocircuits.Frontiers in systems neuroscience · 2019Article
- Spatiotemporal Structure and Dynamics of Spontaneous Oscillatory Synchrony in the Vagal Complex.Frontiers in neuroscience · 2018Article
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5 authors.
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Abstract
Experimental and numerical studies have revealed that isolated populations of oscillatory neurons can spontaneously synchronize and generate periodic bursts involving the whole network. Such a behavior has notably been observed for cultured neurons in rodent's cortex or hippocampus. We show here that a sufficient condition for this network bursting is the presence of an excitatory population of oscillatory neurons which displays spike-driven adaptation. We provide an analytic model to analyze network bursts generated by coupled adaptive exponential integrate-and-fire neurons. We show that, for strong synaptic coupling, intrinsically tonic spiking neurons evolve to reach a synchronized intermittent bursting state. The presence of inhibitory neurons or plastic synapses can then modulate this dynamics in many ways but is not necessary for its appearance. Thanks to a simple self-consistent equation, our model gives an intuitive and semi-quantitative tool to understand the bursting behavior. Furthermore, it suggests that after-hyperpolarization currents are sufficient to explain bursting termination. Through a thorough mapping between the theoretical parameters and ion-channel properties, we discuss the biological mechanisms that could be involved and the relevance of the explored parameter-space. Such an insight enables us to propose experimentally-testable predictions regarding how blocking fast, medium or slow after-hyperpolarization channels would affect the firing rate and burst duration, as well as the interburst interval.
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