Evidence map›Paper›PMID 29467551›Full record

ArticleWorld journal of gastroenterology2018

Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer.

Daniel Brungs, David Lynch, Alison Ws Luk, Elahe Minaei, Marie Ranson, Morteza Aghmesheh, Kara L Vine, Martin Carolan, Mouhannad Jaber, Paul de Souza and 1 more

Open access · hybridAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  7. Technologies for Viable Circulating Tumor Cell Isolation.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Daniel BrungsIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong 2500, Australia.
David LynchCONCERT-Translational Cancer Research Centre, New South Wales 2000, Australia.
Alison Ws LukCONCERT-Translational Cancer Research Centre, New South Wales 2000, Australia.
Elahe MinaeiIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong 2500, Australia.
Marie RansonIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong 2500, Australia.
Morteza AghmeshehIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong 2500, Australia.
Kara L VineIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong 2500, Australia.
Martin CarolanIllawarra Health and Medical Research Institute, University of Wollongong, Wollongong 2500, Australia.
Mouhannad JaberIllawarra Cancer Centre, Wollongong Hospital, Wollongong 2500, Australia.
Paul de SouzaCONCERT-Translational Cancer Research Centre, New South Wales 2000, Australia.
Therese M BeckerCONCERT-Translational Cancer Research Centre, New South Wales 2000, Australia.
Ingham Institute · AUUniversity of Wollongong · AUIllawarra Health and Medical Research Institute · AUWestern Sydney University · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells (PBMCs) for prognostic circulating tumor cell (CTC) detection in gastroesophageal cancer.

methodsUsing 7.5 mL blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the IsoFlux platform. Paired specimens taken during the same blood draw (

resultsWhile there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens (mean number of CTCs 34.4

conclusionPBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing.

Indexed as

Leukocytes, MononuclearAdenocarcinomaAdultAgedAged, 80 and overBiomarkers, TumorCryopreservationEpithelial Cell Adhesion MoleculeEsophageal NeoplasmsEsophagogastric JunctionFeasibility StudiesFemaleHumansImmunohistochemistryImmunomagnetic SeparationMaleBiomarkers, TumorEPCAM protein, humanEpithelial Cell Adhesion MoleculeCirculating tumor cellsCryopreservationGastric cancerGastroesophageal cancerLiquid biopsy

Identifiers

PMID29467551
PMCPMC5807939
OpenAlexW2785752149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.