ArticleScientific reports2018
The mechanistic causes of peripheral intravenous catheter failure based on a parametric computational study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Vascular access devices for prolonged intravenous therapy regimens in people diagnosed with cancer.The Cochrane database of systematic reviews · 2024Pooled it
- Optimization of flushing strategies to minimize dilution of high-concentration radiopharmaceuticals in intravenous tubing.Medical physics · 2026Article
- Evaluating pulsatile flushing by pushing method and catheter size for educating nurses on peripheral vascular patency: a computational fluid dynamics simulation analysis.BMC medical education · 2025Article
- Optimal catheter-to-vein ratios to prevent peripheral venous catheter failure: a single-centre prospective cohort study.British journal of anaesthesia · 2025Article
- Comparison of peripheral intravenous catheterization applied to different anatomical sites in terms of pain, phlebitis and infiltration.BMC nursing · 2025Article
- Mapping existing research on flushing peripheral vascular catheters: a scoping review protocol.BMJ open · 2025Article
- Flushing peripheral intravenous catheters: A scoping review.PloS one · 2025Article
- Quantitative and qualitative investigation of shunt failure in anFrontiers in bioengineering and biotechnology · 2025Article
- Microbiological analysis of tunneled hemodialysis catheters isolated from patients receiving hemodialysis in Saskatchewan.Future microbiology · 2024Article
- Use of Total Parenteral Nutrition (TPN) as a Vehicle for Drug Delivery.Current drug targets · 2024Review
- Investigative study of hemodilution ratio: 4Vs for vein diameter, valve, velocity, and volumetric blood flow as factors for optimal forearm vein selection for intravenous infusion.The journal of vascular access · 2024Article
- Optimizing Infusate Flow Patterns for Minimizing Vein Wall Trauma: An Exploratory Study with a Modified off-Axis Catheter Tip Opening.Therapeutics and clinical risk management · 2024Article
- Clinical placement education during the coronavirus disease 2019 pandemic shapes new nurses: A qualitative study.International journal of nursing studies advances · 2023Article
- Influence of simulation and clinical settings on peripheral vein cannulation skill learning in nursing education: A qualitative study.International journal of nursing studies advances · 2023Article
- Physicochemical Characteristics of Antimicrobials and Practical Recommendations for Intravenous Administration: A Systematic Review.Antibiotics (Basel, Switzerland) · 2023Review
- Sensing Technologies for Extravasation Detection: A Review.ACS sensors · 2023Review
- Novel Design of Peripheral Infusion Catheter Improves the Kinetics of Intravenous Drug Release.Journal of cardiovascular translational research · 2021Article
- Hemodynamic analysis for stenosis microfluidic model of thrombosis with refined computational fluid dynamics simulation.Scientific reports · 2021Article
- Development and Validation of a New Clinical Prediction Model of Catheter-Related Thrombosis Based on Vascular Ultrasound Diagnosis in Cancer Patients.Frontiers in cardiovascular medicine · 2020Article
- Managing hyperglycemia during the COVID-19 pandemic: Improving outcomes using new technologies in intensive care.SAGE open medicine · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral intravenous catheters (PIVCs) are the most commonly used invasive medical device, yet up to 50% fail. Many pathways to failure are mechanistic and related to fluid mechanics, thus can be investigated using computational fluid dynamics (CFD). Here we used CFD to investigate typical PIVC parameters (infusion rate, catheter size, insertion angle and tip position) and report the hemodynamic environment (wall shear stress (WSS), blood damage, particle residence time and venous stasis volumes) within the vein and catheter, and show the effect of each PIVC parameter on each hemodynamic measure. Catheter infusion rate has the greatest impact on our measures, with catheter orientation also playing a significant role. In some PIVC configurations WSS was 3254 times higher than the patent vein, and blood damage was 512 times greater, when compared to control conditions. Residence time is geometry-dependent and decreases exponentially with increasing insertion angle. Stasis volume decreased with increasing infusion rate and, to a lesser degree, insertion angle. Even without infusion, the presence of the catheter changes the flow field, causing low velocity recirculation at the catheter tip. This research demonstrates how several controllable factors impact important mechanisms of PIVC failure. These data, the first of their kind, suggest limiting excessive infusion rates in PIVC.
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