Trial reportScientific reports2018
Development and validation of a clinical prediction model for patient-reported pain and function after primary total knee replacement surgery.
Trial report in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating methodological quality of prognostic prediction models on patient-reported outcome measurements after total hip and total knee arthroplasty : a systematic review.Bone & joint open · 2026Pooled it
- Variation in Outcomes and Number of Visits Following Care Guideline Implementation: Part 2 of an Analysis of 12 355 Patients After Total Knee Arthroplasty.The Journal of orthopaedic and sports physical therapy · 2023Trial
- Factors contributing to 1-year dissatisfaction after total knee arthroplasty: a nomogram prediction model.Journal of orthopaedic surgery and research · 2022Trial
- Outpatient physiotherapy versus home-based rehabilitation for patients at risk of poor outcomes after knee arthroplasty: CORKA RCT.Health technology assessment (Winchester, England) · 2020Trial
- Development of risk prediction model for chronic pain after knee replacement surgery: protocol for an individual patient data meta-analysis.Perioperative medicine (London, England) · 2026Article
- Association between widespread pain and psychosocial factors in people with knee osteoarthritis: a cross-sectional study of patients from primary care in Denmark.Physiotherapy theory and practice · 2025Article
- Bilateral heterotopic ossification following Total knee arthroplasty: The role of cultural practices in postoperative complications: A case report.International journal of surgery case reports · 2025Article
- Computed tomography radiomics in predicting patient satisfaction after robotic-assisted total knee arthroplasty.International journal of computer assisted radiology and surgery · 2025Article
- Metabolic and Immune System Dysregulation: Unraveling the Connections between Alzheimer's Disease, Diabetes, Inflammatory Bowel Diseases, and Rheumatoid Arthritis.Journal of clinical medicine · 2024Review
- Predictors for activity following total and unicompartmental knee arthroplasty.Archives of orthopaedic and trauma surgery · 2023Article
- Using Presurgical Biopsychosocial Features to Develop an Advanced Clinical Decision-Making Support Tool for Predicting Recovery Trajectories in Patients Undergoing Total Knee Arthroplasty: Protocol for a Prospective Observational Study.JMIR research protocols · 2023Article
- Prehabilitation for frail patients undergoing total hip or knee replacement: protocol for the Joint PREP feasibility randomised controlled trial.Pilot and feasibility studies · 2023Article
- Predicting patient-reported outcomes following lumbar spine surgery: development and external validation of multivariable prediction models.BMC musculoskeletal disorders · 2023Article
- Patient appropriateness for total knee arthroplasty and predicted probability of a good outcome.RMD open · 2023Article
- The utility of machine learning algorithms for the prediction of patient-reported outcome measures following primary hip and knee total joint arthroplasty.Archives of orthopaedic and trauma surgery · 2023Article
- Demographics are no clinically relevant predictors of patient-reported knee osteoarthritis symptoms - Comprehensive multivariate analysis.Journal of orthopaedics · 2023Article
- Evaluating methodological quality of prognostic prediction models on patient reported outcome measurements after total hip replacement and total knee replacement surgery: a systematic review protocol.Systematic reviews · 2022Article
- Artificial intelligence in knee arthroplasty: current concept of the available clinical applications.Arthroplasty (London, England) · 2022Review
- Leveraging explainable machine learning to identify gait biomechanical parameters associated with anterior cruciate ligament injury.Scientific reports · 2022Article
- Racial Disparities in Elective Total Joint Arthroplasty for Osteoarthritis.ACR open rheumatology · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
To develop and validate a clinical prediction model of patient-reported pain and function after undergoing total knee replacement (TKR). We used data of 1,649 patients from the Knee Arthroplasty Trial who received primary TKR across 34 centres in the UK. The external validation included 595 patients from Southampton University Hospital, and Nuffield Orthopaedic Centre (Oxford). The outcome was the Oxford Knee Score (OKS) 12-month after TKR. Pre-operative predictors including patient characteristics and clinical factors were considered. Bootstrap backward linear regression analysis was used. Low pre-operative OKS, living in poor areas, high body mass index, and patient-reported anxiety or depression were associated with worse outcome. The clinical factors associated with worse outcome were worse pre-operative physical status, presence of other conditions affecting mobility and previous knee arthroscopy. Presence of fixed flexion deformity and an absent or damaged pre-operative anterior cruciate ligament (compared with intact) were associated with better outcome. Discrimination and calibration statistics were satisfactory. External validation predicted 21.1% of the variance of outcome. This is the first clinical prediction model for predicting self-reported pain and function 12 months after TKR to be externally validated. It will help to inform to patients regarding expectations of the outcome after knee replacement surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.