Evidence map›Paper›PMID 29467445›Full record

ArticleMucosal immunology2018

Vaccine-induced antigen-specific regulatory T cells attenuate the antiviral immunity against acute influenza virus infection.

Pin-Hung Lin, Weng-In Wong, Yi-Lan Wang, Meng-Ping Hsieh, Chia-Wen Lu, Chieh-Yu Liang, Sung-Hsiang Jui, Fang-Yi Wu, Pei-Jer Chen, Hung-Chih Yang

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. T Regulatory Mechanisms in Airway and Interstitial Lung Disease.Seminars in respiratory and critical care medicine · 2025
    Review
  7. Regulatory T cell memory: implications for malaria.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Sex-based differences in persistent lung inflammation following influenza infection of juvenile outbred mice.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Evaluation of the T cell and B cell response following the administration of COVID-19 vaccines in Korea.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2022
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Pin-Hung LinGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Weng-In WongGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Yi-Lan WangGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Meng-Ping HsiehGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chia-Wen LuGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chieh-Yu LiangGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Sung-Hsiang JuiGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Fang-Yi WuGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.
Pei-Jer ChenGraduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Hung-Chih YangGraduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan. hcyang88@ntu.edu.tw.
National Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptide-based T cell vaccines targeting the conserved epitopes of influenza virus can provide cross-protection against distantly related strains, but they are generally not immunogenic. Foreign antigen-specific regulatory T (Treg) cells are induced under subimmunogenic conditions peripherally, although their development and role in vaccine-mediated antiviral immunity is unclear. Here, we demonstrated primary vaccination with peptides alone significantly induced antigen-specific Foxp3

Indexed as

Acute DiseaseAdjuvants, ImmunologicAnimalsAntigens, ViralEpitopes, T-LymphocyteHumansImmunization, SecondaryImmunologic MemoryImmunosuppression TherapyInfluenza, HumanInfluenza VaccinesLymphocyte ActivationMiceMice, Inbred C57BLMice, TransgenicOligodeoxyribonucleotidesAdjuvants, ImmunologicAntigens, ViralEpitopes, T-LymphocyteInfluenza VaccinesOligodeoxyribonucleotidesVaccines, Subunit

Identifiers

PMID29467445
OpenAlexW2793767391

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.