Evidence map›Paper›PMID 29467437›Full record

Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

Accelerated repetitive transcranial magnetic stimulation in the treatment of depression.

Paul B Fitzgerald, Kate E Hoy, David Elliot, R N Susan McQueen, Lenore E Wambeek, Zafiris J Daskalakis

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 54 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 10 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03626181 naunknown statusnot on this map

Using Multiple Brain-based Biomarkers to Validate and Predict Response to Theta Burst Stimulation as a New Treatment for Major Depressive Disorder

TypeinterventionalSponsorUniversity of CalgaryRan2018 to 2019Enrolled30ConditionsDepressive Disorder, Treatment-ResistantArmsTheta Burst Stimulation ( Transcranial Magnetic Stimulation)
NCT04257227 nacompletednot on this mapstarted 2020, after this paper: background citation

Transcranial Magnetic Stimulation for Psychological Distress in Patients With Advanced Illness: A Phase 2a/2b Dose-finding and Feasibility Clinical Trial

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2020 to 2024Enrolled13ConditionsDepressive Symptoms, Depression, Anxiety, Psychological Distress, Terminal IllnessArmsrepetitive Transcranial Magnetic Stimulation (rTMS)
3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 10 syntheses or guidelines pooled it, 147 citations in OpenAlex.

  1. Pooled it
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  4. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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  13. Accelerated sequential bilateral theta-burst stimulation in major depression: an open trial.European archives of psychiatry and clinical neuroscience · 2024
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  14. Treatment of mixed depression with theta-burst stimulation (TBS): results from a double-blind, randomized, sham-controlled clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Paul B FitzgeraldEpworth Healthcare, The Epworth Clinic, Camberwell, Victoria, Australia. paul.fitzgerald@monash.edu.
Kate E HoyMonash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Victoria, Australia.
David ElliotMonash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Victoria, Australia.
R N Susan McQueenMonash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Victoria, Australia.
Lenore E WambeekMonash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Victoria, Australia.
Zafiris J DaskalakisDepartment of Psychiatry, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada.
Monash University · AUEpworth Hospital · AUMonash Alfred Psychiatry Research centre · AUUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is increasingly used clinically in the treatment of patients with major depressive disorder (MDD). However, rTMS treatment response can be slow. Early research suggests that accelerated forms of rTMS may be effective but no research has directly evaluated a schedule of accelerated rTMS compared to standard rTMS. To assess the efficacy of accelerated rTMS compared to standard daily rTMS., 115 outpatients with MDD received either accelerated rTMS (n = 58) (i.e., 63,000 high frequency rTMS pulses delivered as 3 treatments per day over 3 days in week 1, 3 treatments over 2 days in week 2 and 3 treatments on a single day in week 3) or standard rTMS (n = 57) (i.e., 63,000 total high frequency rTMS pulses delivered over 5 days per week for 4 weeks) following randomization. There were no significant differences in remission or response rates (p > 0.05 for all analyses) or reduction in depression scores (Time by group interaction (F (5, 489.452) = 1.711, p = 0.130) between the accelerated and standard rTMS treatment groups. Accelerated treatment was associated with a higher rate of reported treatment discomfort. It is feasible to provide accelerated rTMS treatment for outpatients with depression and this is likely to produce meaningful antidepressant effects.

Indexed as

FemaleHumansMajor Depressive DisorderMaleMiddle AgedPrefrontal CortexSingle-Blind MethodTime FactorsTranscranial Direct Current StimulationTreatment Outcome

Identifiers

PMID29467437
PMCPMC5983543
OpenAlexW2792569638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.