ArticleScientific reports2018
Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Comparative morphogenesis of mouse and rat mandibular first molars (M1): a review of developmental timing, structure, and signaling pathways.Anatomy & cell biology · 2026Review
- Endothelial Nitric Oxide Synthase Restores Diabetic Dentin Regeneration via AKT/Endothelial Nitric Oxide Synthase Axis.International dental journal · 2026Article
- Overexpression of interleukin-4 using adeno-associated virus is a potential strategy to enhance bone regeneration.JBMR plus · 2025Article
- Role of Pyrrolidine dithiocarbamate in inducing odontoblastic differentiation of dental pulp stem cells.Journal of conservative dentistry and endodontics · 2024Article
- Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease.Scientific reports · 2024Article
- Article
- Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence.Materials today. Bio · 2023Article
- Physiologic dentin regeneration: its past, present, and future perspectives.Frontiers in physiology · 2023Review
- Application of Dental Pulp Stem Cells for Bone and Neural Tissue Regeneration in Oral and Maxillofacial Region.Stem cells international · 2023Review
- NBCe1 Regulates Odontogenic Differentiation of Human Dental Pulp Stem Cells via NF-International journal of stem cells · 2022Article
- The Inhibition of the Inducible Nitric Oxide Synthase Enhances the DPSC Mineralization under LPS-Induced Inflammation.International journal of molecular sciences · 2022Article
- Protocol to generate xenogeneic-free/serum-free human dental pulp stem cells.STAR protocols · 2022Article
- A New Target of Dental Pulp-Derived Stem Cell-Based Therapy on Recipient Bone Marrow Niche in Systemic Lupus Erythematosus.International journal of molecular sciences · 2022Review
- The Role of Nitric Oxide in Stem Cell Biology.Antioxidants (Basel, Switzerland) · 2022Review
- Naringin Promotes Osteogenic/Odontogenic Differentiation of Dental Pulp Stem Cells via Wnt/Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Phenytoin Is Promoting the Differentiation of Dental Pulp Stem Cells into the Direction of Odontogenesis/Osteogenesis by Activating BMP4/Smad Pathway.Disease markers · 2022Article
- Relevance of Cellular Redox Homeostasis for Vital Functions of Human Dental Pulp Cells.Antioxidants (Basel, Switzerland) · 2021Article
- Tailoring Silicon Nitride Surface Chemistry for Facilitating Odontogenic Differentiation of Rat Dental Pulp Cells.International journal of molecular sciences · 2021Article
- [Nerve growth factor combined with dental pulp stem cells promotes peri-implant osseointegration in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Knockdown of microRNA-584 promotes dental pulp stem cells proliferation by targeting TAZ.Cell cycle (Georgetown, Tex.) · 2020Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitric oxide (NO) is thought to play a pivotal regulatory role in dental pulp tissues under both physiological and pathological conditions. However, little is known about the NO functions in dental pulp stem cells (DPSCs). We examined the direct actions of a spontaneous NO gas-releasing donor, NOC-18, on the odontogenic capacity of rat DPSCs (rDPSCs). In the presence of NOC-18, rDPSCs were transformed into odontoblast-like cells with long cytoplasmic processes and a polarized nucleus. NOC-18 treatment increased alkaline phosphatase activity and enhanced dentin-like mineralized tissue formation and the expression levels of several odontoblast-specific genes, such as runt related factor 2, dentin matrix protein 1 and dentin sialophosphoprotein, in rDPSCs. In contrast, carboxy-PTIO, a NO scavenger, completely suppressed the odontogenic capacity of rDPSCs. This NO-promoted odontogenic differentiation was activated by tumor necrosis factor-NF-κB axis in rDPSCs. Further in vivo study demonstrated that NOC-18-application in a tooth cavity accelerated tertiary dentin formation, which was associated with early nitrotyrosine expression in the dental pulp tissues beneath the cavity. Taken together, the present findings indicate that exogenous NO directly induces the odontogenic capacity of rDPSCs, suggesting that NO donors might offer a novel host DPSC-targeting alternative to current pulp capping agents in endodontics.
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