ArticleThe ISME journal2018
A virus or more in (nearly) every cell: ubiquitous networks of virus-host interactions in extreme environments.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
68 citing papers in PubMed, 122 citations in OpenAlex.
- Toxic Relationships: Characterization of a Putative Virally Encoded Toxin in the Thermophilic Archaeal Fusellovirus SSV1.Viruses · 2026Article
- Host-linked virome assembly and turnover predict bacterial community structure in wastewater treatment systems.The ISME journal · 2026Article
- Viral Dark Matter: Illuminating Protein Function, Ecology, and Biotechnological Promises.Biochemistry · 2025Review
- A previously undescribed archaeal virus suppresses host immunity.EMBO reports · 2025Article
- Single-particle genomics uncovers abundant non-canonical marine viruses from nanolitre volumes.Nature microbiology · 2025Article
- Viral Dark Matter: Illuminating Protein Function, Ecology, and Biotechnological Promises.ArXiv · 2025Article
- Two novel polyvalent phages: a promising approach for cross-order pathogen control in aquaculture.Virology journal · 2025Article
- Broad host range phage LPC-1 reduce the risk of Listeria monocytogenes contamination in different food matrices.Archives of microbiology · 2025Article
- Review
- Novel viruses of Haloquadratum walsbyi expand the known archaeal virosphere of hypersaline environments.The ISME journal · 2025Article
- Adaptive genomic plasticity in large-genome, broad-host-range vibrio phages.The ISME journal · 2025Article
- Contrasting defense strategies of oligotrophs and copiotrophs revealed by single-cell-resolved virus-host pairing of freshwater bacteria.ISME communications · 2025Article
- Provirus deletion frommicroLife · 2025Article
- Diverse phage communities are maintained stably on a clonal bacterial host.Science (New York, N.Y.) · 2024Article
- Adaptive expression of phage auxiliary metabolic genes in paddy soils and their contribution toward global carbon sequestration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Sequencing-based analysis of microbiomes.Nature reviews. Genetics · 2024Review
- Inferring strain-level mutational drivers of phage-bacteria interaction phenotypes arising during coevolutionary dynamics.bioRxiv : the preprint server for biology · 2024Article
- Does Phage Therapy Need a Pan-Phage?Pathogens (Basel, Switzerland) · 2024Review
- Evolutionary Adaptation of an RNA Bacteriophage to Repeated Freezing and Thawing Cycles.International journal of molecular sciences · 2024Article
- The Expanding Diversity of Viruses from Extreme Environments.International journal of molecular sciences · 2024Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of viral and cellular metagenomics to natural environments has expanded our understanding of the structure, functioning, and diversity of microbial and viral communities. The high diversity of many communities, e.g., soils, surface ocean waters, and animal-associated microbiomes, make it difficult to establish virus-host associations at the single cell (rather than population) level, assign cellular hosts, or determine the extent of viral host range from metagenomics studies alone. Here, we combine single-cell sequencing with environmental metagenomics to characterize the structure of virus-host associations in a Yellowstone National Park (YNP) hot spring microbial community. Leveraging the relatively low diversity of the YNP environment, we are able to overlay evidence at the single-cell level with contextualized viral and cellular community structure. Combining evidence from hexanucelotide analysis, single cell read mapping, network-based analytics, and CRISPR-based inference, we conservatively estimate that >60% of cells contain at least one virus type and a majority of these cells contain two or more virus types. Of the detected virus types, nearly 50% were found in more than 2 cellular clades, indicative of a broad host range. The new lens provided by the combination of metaviromics and single-cell genomics reveals a network of virus-host interactions in extreme environments, provides evidence that extensive virus-host associations are common, and further expands the unseen impact of viruses on cellular life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.