Evidence map›Paper›PMID 29467316›Full record

ArticleJournal of virology2018

Formation of RNA Granule-Derived Capsid Assembly Intermediates Appears To Be Conserved between Human Immunodeficiency Virus Type 1 and the Nonprimate Lentivirus Feline Immunodeficiency Virus.

Jonathan C Reed, Nick Westergreen, Brook C Barajas, Dylan T B Ressler, Daryl J Phuong, John V Swain, Vishwanath R Lingappa, Jaisri R Lingappa

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Article
  9. Strategies for Success. Viral Infections and Membraneless Organelles.Frontiers in cellular and infection microbiology · 2019
    Review
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jonathan C ReedProsetta Biosciences, San Francisco, California, USA jreed@prosetta.com.
Nick WestergreenProsetta Biosciences, San Francisco, California, USA.
Brook C BarajasDepartment of Global Health, University of Washington, Seattle, Washington, USA.
Dylan T B ResslerProsetta Biosciences, San Francisco, California, USA.
Daryl J PhuongDepartment of Global Health, University of Washington, Seattle, Washington, USA.
John V SwainProsetta Biosciences, San Francisco, California, USA.
Vishwanath R LingappaProsetta Biosciences, San Francisco, California, USA.
Jaisri R LingappaDepartment of Global Health, University of Washington, Seattle, Washington, USA.
University of Washington · US

Funding

HIV-1 capsid assembly intermediates: cellular factors and links to pathogenesisR01AI106397 · NIAID · UNIVERSITY OF WASHINGTON · PI LINGAPPA, JAISRI R · 2013 to 2017
$2.1M
NIAID NIH HHS R01 AI106397
6 · The paper itself

Abstract

During immature capsid assembly in cells, human immunodeficiency virus type 1 (HIV-1) Gag co-opts a host RNA granule, forming a pathway of intracellular assembly intermediates containing host components, including two cellular facilitators of assembly, ABCE1 and DDX6. A similar assembly pathway has been observed for other primate lentiviruses. Here we asked whether feline immunodeficiency virus (FIV), a nonprimate lentivirus, also forms RNA granule-derived capsid assembly intermediates. First, we showed that the released FIV immature capsid and a large FIV Gag-containing intracellular complex are unstable during analysis, unlike for HIV-1. We identified harvest conditions, including

Indexed as

AnimalsATP-Binding Cassette TransportersCapsidCapsid ProteinsCatsCell LineChlorocebus aethiopsCOS CellsDEAD-box RNA HelicasesEndoribonucleasesGene Products, gagHIV-1Immunodeficiency Virus, FelineRNA-Binding ProteinsVirus AssemblyATP-Binding Cassette TransportersCapsid ProteinsDEAD-box RNA HelicasesEndoribonucleasesGene Products, gagRNA-Binding ProteinsABCE1DCP2DDX6FIVGagHIVimmature capsid assembly

Identifiers

PMID29467316
PMCPMC5899207
OpenAlexW2790492979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.