Evidence map›Paper›PMID 29467285›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA.

H S Jeffrey Man, Aravin N Sukumar, Gabrielle C Lam, Paul J Turgeon, Matthew S Yan, Kyung Ha Ku, Michelle K Dubinsky, J J David Ho, Jenny Jing Wang, Sunit Das and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Subcellular Localization Guides eNOS Function.International journal of molecular sciences · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. Epigenetic Regulation of Angiogenesis in Peripheral Artery Disease.Methodist DeBakey cardiovascular journal · 2023
    Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

H S Jeffrey ManInstitute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
Aravin N SukumarInstitute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
Gabrielle C LamDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.
Paul J TurgeonKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON M5B 1T8, Canada.
Matthew S YanKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON M5B 1T8, Canada.
Kyung Ha KuKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON M5B 1T8, Canada.
Michelle K DubinskyInstitute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
J J David HoKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON M5B 1T8, Canada.
Jenny Jing WangKeenan Research Centre for Biomedical Science in the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, ON M5B 1T8, Canada.
Sunit DasArthur and Sonia Labatt Brain Tumour Research Institute, Hospital for SickKids, University of Toronto, Toronto, ON M5G 1X8, Canada.
Nora MitchellDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115.
Peter OettgenDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115.
Michael V SeftonDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E2, Canada.
Philip A MarsdenInstitute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada; p.marsden@utoronto.ca.
University of Toronto · CASt. Michael's Hospital · CABeth Israel Deaconess Medical Center · USHarvard University · US

Funding

CIHR MOP 142307
6 · The paper itself

Abstract

Endothelial cell (EC)-enriched protein coding genes, such as endothelial nitric oxide synthase (eNOS), define quintessential EC-specific physiologic functions. It is not clear whether long noncoding RNAs (lncRNAs) also define cardiovascular cell type-specific phenotypes, especially in the vascular endothelium. Here, we report the existence of a set of EC-enriched lncRNAs and define a role for

Indexed as

Endothelial CellsNeovascularization, PhysiologicRNA, Long NoncodingAnimalsCells, CulturedChromatinEndothelium, VascularHemodynamicsHumansHuman Umbilical Vein Endothelial CellsMiceMice, SCIDChromatinRNA, Long Noncodingangiogenesischromatinendotheliumhemodynamicslong noncoding RNA

Identifiers

PMID29467285
PMCPMC5877935
OpenAlexW2790752017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.