Evidence map›Paper›PMID 29467256›Full record

ArticleMolecular biology of the cell2018

Commonly used trafficking blocks disrupt ARF1 activation and the localization and function of specific Golgi proteins.

Catherine E Gilbert, Elizabeth Sztul, Carolyn E Machamer

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Common Assays in Mammalian Golgi Studies.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Cross-Kingdom Activation ofJournal of bacteriology · 2020
    Review
  12. ARF family GTPases with links to cilia.American journal of physiology. Cell physiology · 2020
    Review
  13. Review
  14. Review
  15. Effects of Arf6 downregulation on biological characteristics of human prostate cancer cells.International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Catherine E GilbertDepartment of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Elizabeth SztulDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35924.
Carolyn E MachamerDepartment of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Johns Hopkins University · USUniversity of Alabama at Birmingham · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Spatio-temporal regulation of ARF signaling in vesicle formationR01GM122802 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SZTUL, ELIZABETH S · 2017 to 2020
$1.5M
Accommodation of large cargo within Golgi cisternaeR01GM117399 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI MACHAMER, CAROLYN E · 2016 to 2019
$1.4M
NIDDK NIH HHS P30 DK079626NIGMS NIH HHS R01 GM117399NIGMS NIH HHS R01 GM122802NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Cold temperature blocks used to synchronize protein trafficking inhibit GBF1 function, leading to a decrease in ARF1-GTP levels and mislocalization of the ARF1 effector golgin-160. Several other, but not all, Golgi proteins including ARL1 also mislocalize. ARF1 activity and golgin-160 localization require more than 30 min to recover from these blocks.

Indexed as

Protein TransportADP-Ribosylation Factor 1AutoantigensCold TemperatureGolgi Matrix ProteinsGuanine Nucleotide Exchange FactorsHeLa CellsHumanstrans-Golgi NetworkADP-Ribosylation Factor 1AutoantigensGBF1 protein, humanGOLGA3 protein, humanGolgi Matrix ProteinsGuanine Nucleotide Exchange Factors

Identifiers

PMID29467256
PMCPMC5896932
OpenAlexW2790721241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.