Evidence map›Paper›PMID 29467253›Full record

ArticleMolecular biology of the cell2018

Membrane detachment is not essential for COG complex function.

Leslie K Climer, Irina D Pokrovskaya, Jessica B Blackburn, Vladimir V Lupashin

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Golgi inCOGnito: From vesicle tethering to human disease.Biochimica et biophysica acta. General subjects · 2020
    Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Leslie K ClimerCollege of Medicine, Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205.
Irina D PokrovskayaCollege of Medicine, Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205.
Jessica B BlackburnCollege of Medicine, Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205.
Vladimir V LupashinCollege of Medicine, Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205.

Funding

Study of the Cell-specific Inflammasome Responses During Defense Against Gram-negative BacteriaP20GM103625 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI SMELTZER, MARK S · 2012 to 2021
$21.5M
Characterization of mammalian COG complex-interacting intra-Golgi trafficking macR01GM083144 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI VLADIMIR V LUPASHIN · 2008 to 2026
$6.5M
Super-Res Holographic Microscopy to Advance Research on Golgi Apparatus FunctionU54GM105814 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BROOKER, GARY, LUPASHIN, VLADIMIR V · 2013 to 2017
$2.1M
Super-Resolution Light Microscope at University of Arkansas for Medical SciencesS10OD018065 · OD · UNIV OF ARKANSAS FOR MED SCIS · PI STORRIE, BRIAN · 2015 to 2015
$600k
NIGMS NIH HHS P20 GM103625NIGMS NIH HHS R01 GM083144NIGMS NIH HHS U54 GM105814NIH HHS S10 OD018065
6 · The paper itself

Abstract

COG is a multisubunit vesicle tethering complex in the Golgi. We demonstrate that both COG subcomplexes can be permanently attached to Golgi membranes and that major COG functions do not require cycling between the membrane and cytosol.

Indexed as

Adaptor Proteins, Vesicular TransportGlycosylationGolgi ApparatusHEK293 CellsHumansMembrane ProteinsProtein SubunitsProtein TransportVesicular Transport ProteinsAdaptor Proteins, Vesicular TransportCOG4 protein, humanCOG7 protein, humanCOG8 protein, humanMembrane ProteinsProtein SubunitsTMEM115 protein, humanVesicular Transport Proteins

Identifiers

PMID29467253
PMCPMC5896934

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.