Evidence map›Paper›PMID 29467252›Full record

ArticleMolecular biology of the cell2018

Yeast Aim21/Tda2 both regulates free actin by reducing barbed end assembly and forms a complex with Cap1/Cap2 to balance actin assembly between patches and cables.

Myungjoo Shin, Jolanda van Leeuwen, Charles Boone, Anthony Bretscher

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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  13. TheJournal of cell science · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Myungjoo ShinDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.
Jolanda van LeeuwenDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Charles BooneDonnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada.
Anthony BretscherDepartment of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.

Funding

MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAER01GM039066 · NIGMS · CORNELL UNIVERSITY ITHACA · PI BRETSCHER, ANTHONY P. · 1988 to 2018
$7.3M
NIGMS NIH HHS R01 GM039066
6 · The paper itself

Abstract

Yeast Aim21 is recruited by the SH3-containing proteins Bbc1 and Abp1 to patches and, with Tda2, reduces barbed end assembly to balance the distribution of actin between patches and cables. Aim21/Tda2 also interacts with Cap1/Cap2, revealing a complex interplay between actin assembly regulators.

Indexed as

EndocytosisActin Capping ProteinsActin CytoskeletonActinsCytoskeletal ProteinsGenotypeMicrofilament ProteinsMicroscopy, FluorescenceModels, MolecularMutationProtein BindingProtein ConformationSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionABP1 protein, S cerevisiaeActin Capping ProteinsActinsBBC1 protein, S cerevisiaeCAP1 protein, S cerevisiaeCap2 protein, S cerevisiaeCytoskeletal ProteinsMicrofilament ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID29467252
PMCPMC5896931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.