Evidence map›Paper›PMID 29467251›Full record

ArticleMolecular biology of the cell2018

The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length.

Emily L Hunter, Karl Lechtreck, Gang Fu, Juyeon Hwang, Huawen Lin, Avanti Gokhale, Lea M Alford, Brian Lewis, Ryosuke Yamamoto, Ritsu Kamiya and 5 more

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 43 citations in OpenAlex.

  1. Functions and trafficking mechanisms of RIC-8 inMolecular biology of the cell · 2026
    Article
  2. Article
  3. Review
  4. The intraflagellar transport cycle.Nature reviews. Molecular cell biology · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. eLife · 2022
    Article
  16. Article
  17. Structural organization of the intermediate and light chain complex of Chlamydomonas ciliary I1 dynein.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  18. Article
  19. Article
  20. Asymmetries in the cilia ofPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 2 countries.

Emily L HunterDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
Karl LechtreckDepartment of Cellular Biology, University of Georgia, Athens, GA 30602.
Gang FuDepartments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Juyeon HwangDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
Huawen LinDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Avanti GokhaleDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
Lea M AlfordDepartment of Biology, Oglethorpe University, Atlanta, GA 30319.
Brian LewisDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Ryosuke YamamotoDepartment of Biological Sciences, Osaka University, Osaka 560-0043, Japan.
Ritsu KamiyaDepartment of Biological Sciences, Chuo University, Tokyo 112-8551, Japan.
Fan YangDepartment of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216.
Daniela NicastroDepartments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Susan K DutcherDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Maureen WirschellDepartment of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216.
Winfield S SaleDepartment of Cell Biology, Emory University, Atlanta, GA 30322.
Emory University · USWashington University in St. Louis · USThe University of Texas Southwestern Medical Center · USUniversity of Mississippi Medical Center · USChuo University · JPOglethorpe University · USThe University of Osaka · JPUniversity of Georgia · US

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
REGULATION OF MOTILE CILIA ASSEMBLY IN LUNG DISEASER01HL128370 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, SUSAN K DUTCHER · 2015 to 2026
$6.9M
Structure and Function of Complexes that Regulate Ciliary MotilityR01GM083122 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Daniela Nicastro · 2007 to 2026
$6.2M
Training Program in Biochemistry, Cell and Molecular BiologyT32GM008367 · NIGMS · EMORY UNIVERSITY · PI BOISE, LAWRENCE H., CORBETT, ANITA H. · 1990 to 2019
$5.6M
Functional Substructure of Flagellar DyneinR37GM051173 · NIGMS · EMORY UNIVERSITY · PI SALE, WINFIELD S · 2002 to 2011
$4.0M
FUNCTIONAL SUBSTRUCTURE OF FLAGELLAR DYNEINR01GM051173 · NIGMS · EMORY UNIVERSITY · PI SALE, WINFIELD S · 1994 to 2020
$3.6M
NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR002378NHLBI NIH HHS R01 HL128370NIGMS NIH HHS R01 GM051173NIGMS NIH HHS R01 GM083122NIGMS NIH HHS R37 GM051173NIGMS NIH HHS T32 GM008367
6 · The paper itself

Abstract

We determined how the ciliary motor I1 dynein is transported. A specialized adapter, IDA3, facilitates I1 dynein attachment to the ciliary transporter called intraflagellar transport (IFT). Loading of IDA3 and I1 dynein on IFT is regulated by ciliary length.

Indexed as

AxonemeChlamydomonasCiliaDyneinsFlagellaKinesinsModels, BiologicalMutationPlant ProteinsProtein BiosynthesisProtein TransportDyneinsKinesinsPlant Proteins

Identifiers

PMID29467251
PMCPMC5896928
OpenAlexW2790725738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.