ArticleThe EMBO journal2018
Regenerative proliferation of differentiated cells by mTORC1-dependent paligenosis.
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Article in The EMBO journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
127 citing papers in PubMed, 1 synthesis or guideline pooled it, 196 citations in OpenAlex.
- Global research trends in signaling pathways of spasmolytic polypeptide-expressing metaplasia pathogenesis: a bibliometric analysis.Frontiers in oncology · 2025Pooled it
- Review
- The origins and progression of pyloric metaplasia following gastric mucosal injury.Physiological reviews · 2026Review
- Chrono-atlas of cell-type specific daily gene expression rhythms in the regenerating colon.Nature communications · 2026Article
- miR-1-3p, as a novel diagnostic and prognostic biomarker, aggravates pancreatic acinar cell injury in acute pancreatitis by targeting GNPTAB.Hereditas · 2026Article
- Basal gland localization and focal distribution of OLFM4-expressing cells in increasing severity of gastric intestinal metaplasia.bioRxiv : the preprint server for biology · 2026Article
- Stress-Responsive Protein IFRD1 Protects Assembled Ribosomes via a Ribosome-Salvaging Mechanism.bioRxiv : the preprint server for biology · 2026Article
- Regulation of STK38 by autophagy governs YAP1 activity during paligenosis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evidence that injury can causebioRxiv : the preprint server for biology · 2026Article
- Recent advances in spasmolytic polypeptide expressing metaplasia research.World journal of gastrointestinal oncology · 2026Review
- Paligenosis: dual potential of mature cell plasticity in regeneration and tumorigenesis.MedScience · 2026Review
- Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience.Communications biology · 2026Article
- Endoscopic and histopathological phenotypes of early gastric neoplasia: toward an integrative host-response framework.Frontiers in oncology · 2026Review
- Heparanase 2 (Hpa2) protects the exocrine pancreas from damages of Western diet and pancreatic cancer.International journal of biological sciences · 2026Article
- Glycolytic reprogramming in precancerous lesions of gastric cancer progression: pathogenesis and therapeutic potential.Frontiers in oncology · 2026Review
- Review
- Acinar-derived VEGF-A orchestrates blood vascular remodeling and preserves microvessels during acute pancreatitis.Cell communication and signaling : CCS · 2025Article
- Gastric hypoplasia in mice lacking fibroblast growth factor 9.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Article
- Intestinal injury and repair: insights from hyaline fibromatosis syndrome.EMBO molecular medicine · 2025Article
- Injury-induced intestinal stem cell renewal requires capillary morphogenesis gene 2.EMBO molecular medicine · 2025Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Spencer G WilletDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Mark A LewisDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Zhi-Feng MiaoDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Dengqun LiuState Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
Megan D RadykDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Rebecca L CunninghamDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Joseph BurclaffDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Greg SibbelDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Hei-Yong G LoDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Valerie BlancDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Nicholas O DavidsonDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Zhen-Ning WangDepartment of Surgical Oncology and General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China josieon826@sina.cn jmills@wustl.edu.ORCID 0000-0003-0557-3097
Jason C MillsDivision of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA josieon826@sina.cn jmills@wustl.edu.ORCID 0000-0002-0402-4662
Washington University in St. Louis · USArmy Medical University · CNFirst Hospital of China Medical University · CN
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MWU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1MTRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4MREGULATION OF ATROPHY-INDUCED PROGENITOR CELLS IN THE GASTRIC CORPUSR01DK094989 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2012 to 2026
$6.1MHEPATIC SYNTHESIS AND SECRETION OF APOLIPOPROTEIN (A)R01DK056260 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1999 to 2017
$5.9MMECHANISMS OF CHIEF CELL DEDIFFERENTIATIONR01DK105129 · NIDDK · WASHINGTON UNIVERSITY · PI Jason C Mills · 2015 to 2026
$5.4MENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESIS.R37HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 2000 to 2009
$5.1MENTEROHEPATIC LIPID FLUX AND APOPROTEIN BIOSYNTHESISR01HL038180 · NHLBI · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O. · 1986 to 2018
$3.8MThe Role of EBI3 in Regulating Gastritis and Gastric CarcinogenesisR01DK110406 · NIDDK · SAINT LOUIS UNIVERSITY · PI DIPAOLO, RICHARD J · 2016 to 2020
$2.3MBile acid metabolomics and metagenomics in short bowel syndromeR01DK112378 · NIDDK · WASHINGTON UNIVERSITY · PI DAVIDSON, NICHOLAS O., RUBIN, DEBORAH C. · 2016 to 2018
$1.1MThe Role of Inflammation in Regulating Gastritis and Gastric CarcinogenesisR56DK110406 · NIDDK · SAINT LOUIS UNIVERSITY · PI DIPAOLO, RICHARD J · 2021 to 2021
$486kNCI NIH HHS P30 CA091842NHLBI NIH HHS R01 HL038180NHLBI NIH HHS R37 HL038180NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK056260NIDDK NIH HHS R01 DK094989NIDDK NIH HHS R01 DK105129NIDDK NIH HHS R01 DK110406NIDDK NIH HHS R01 DK112378NIDDK NIH HHS R56 DK110406NIGMS NIH HHS T32 GM007067
Abstract
In 1900, Adami speculated that a sequence of context-independent energetic and structural changes governed the reversion of differentiated cells to a proliferative, regenerative state. Accordingly, we show here that differentiated cells in diverse organs become proliferative via a shared program. Metaplasia-inducing injury caused both gastric chief and pancreatic acinar cells to decrease mTORC1 activity and massively upregulate lysosomes/autophagosomes; then increase damage associated metaplastic genes such as
Indexed as
Acinar CellsAnimalsAutophagosomesCell CycleCell DifferentiationCell ProliferationCell TransdifferentiationCellular ReprogrammingChief Cells, GastricGastrointestinal TractGene ExpressionHumansLysosomesMechanistic Target of Rapamycin Complex 1MetaplasiaMiceGNPTAB protein, mouseMechanistic Target of Rapamycin Complex 1Sox9 protein, mouseSOX9 Transcription FactorTransferases (Other Substituted Phosphate Groups)dedifferentiationregenerationrepairreprogrammingtransdifferentiation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.