ArticleBMC research notes2018
Diurnal variation of NMDA receptor expression in the rat cerebral cortex is associated with traumatic brain injury damage.
Article in BMC research notes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 22 citations in OpenAlex.
- The effect of thioredoxin-1 in a rat model of traumatic brain injury depending on diurnal variation.Brain and behavior · 2023Article
- Article
- Role of circadian rhythms in pathogenesis of acute CNS injuries: Insights from experimental studies.Experimental neurology · 2022Review
- Plasticity impairment alters community structure but permits successful pattern separation in a hippocampal network model.Frontiers in cellular neuroscience · 2022Article
- Effects of time-of-day on the concentration of defined excitatory and inhibitory amino acids in the cerebrospinal fluid of rats: a microdialysis study.Amino acids · 2021Article
- Differences in Diurnal Variation of Immune Responses in Microglia and Macrophages: Review and Perspectives.Cellular and molecular neurobiology · 2020Review
- Diurnal Variation Induces Neurobehavioral and Neuropathological Differences in a Rat Model of Traumatic Brain Injury.Frontiers in neuroscience · 2020Article
- Sleep and Circadian Medicine: Time of Day in the Neurologic Clinic.Neurologic clinics · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveData from our laboratory suggest that recovery from a traumatic brain injury depends on the time of day at which it occurred. In this study, we examined whether traumatic brain injury -induced damage is related to circadian variation in N-methyl-D-aspartate receptor expression in rat cortex.
resultsWe confirmed that traumatic brain injury recovery depended on the time of day at which the damage occurred. We also found that motor cortex N-methyl-D-aspartate receptor subunit NR1 expression exhibited diurnal variation in both control and traumatic brain injury-subjected rats. However, this rhythm is more pronounced in traumatic brain injury-subjected rats, with minimum expression in those injured during nighttime hours. These findings suggest that traumatic brain injury occurrence times should be considered in future clinical studies and when designing neuroprotective strategies for patients.
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Registered trials
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