ArticleNutrition journal2018
Association between plasma fatty acids and inflammatory markers in patients with and without insulin resistance and in secondary prevention of cardiovascular disease, a cross-sectional study.
Article in Nutrition journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Association of Polyunsaturated Fatty Acid Intake on Inflammatory Gene Expression and Multiple Sclerosis: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- Impact of α-Linolenic Acid, the Vegetable ω-3 Fatty Acid, on Cardiovascular Disease and Cognition.Advances in nutrition (Bethesda, Md.) · 2022Pooled it
- Postprandial Fatty Acid Profile, but Not Cardiometabolic Risk Markers, Is Modulated by Dairy Fat Manipulation in Adults with Moderate Cardiovascular Disease Risk: The Randomized Controlled REplacement of SaturatEd fat in dairy on Total cholesterol (RESET) Study.The Journal of nutrition · 2021Trial
- Triglyceride-Glucose Index Modifies Mortality Risk Across Body Mass Index Strata in Critically Ill Patients: A Retrospective Cohort Analysis of the MIMIC-IV Database.Journal of clinical medicine · 2026Article
- Association between estimated glucose disposal rate and cardiovascular mortality in postmenopausal women: a national cohort study.Nutrition & metabolism · 2026Article
- Triglyceride-glucose index predicts the mortality risk among incident peritoneal dialysis patients in a cohort study.Scientific reports · 2025Observational
- Associations between omega-3 fatty acid-derived lipid mediators and markers of inflammation in older subjects with low-grade chronic inflammation.Prostaglandins & other lipid mediators · 2025Article
- Unraveling the Interaction between Inflammation and the Cardiometabolic Index in Older Men: A Pilot Study.Nutrients · 2024Observational
- The Predictive Value of TyG Index and NLR for Risk of CHD and the Severity of Coronary Artery Lesions in Patients with Type 2 Diabetes Mellitus.Journal of inflammation research · 2024Article
- Insulin Resistance and Hypertension: Mechanisms Involved and Modifying Factors for Effective Glucose Control.Biomedicines · 2023Review
- Dietary Fatty Acids and Inflammation: Focus on the n-6 Series.International journal of molecular sciences · 2023Review
- Association between triglyceride-glucose index and risk of cardiovascular disease among postmenopausal women.Cardiovascular diabetology · 2023Article
- Time course of the triglyceride glucose index accumulation with the risk of cardiovascular disease and all-cause mortality.Cardiovascular diabetology · 2022Article
- Association between the triglyceride-glucose index and severity of coronary artery disease.Cardiovascular diabetology · 2022Article
- Characterization of Buriti (Nutrients · 2022Article
- Article
- Integrating pharmacological evaluation and computational identification for deciphering the action mechanism of Yunpi-Huoxue-Sanjie formula alleviates diabetic cardiomyopathy.Frontiers in pharmacology · 2022Article
- Estimating the viral loads of SARS-CoV-2 in the oral cavity when complicated with periapical lesions.BMC oral health · 2021Article
- Change in triglyceride-glucose index predicts the risk of cardiovascular disease in the general population: a prospective cohort study.Cardiovascular diabetology · 2021Observational
- Triglyceride-glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort.Cardiovascular diabetology · 2021Observational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProinflammatory biomarkers levels are increased among patients with cardiovascular disease, and it is known that both the presence of insulin resistance and diet may influence those levels. However, these associations are not well studied among patients with established cardiovascular disease. Our objective is to compare inflammatory biomarker levels among cardiovascular disease secondary prevention patients with and without insulin resistance, and to evaluate if there is any association between plasma fatty acid levels and inflammatory biomarker levels among them.
methodsIn this cross-sectional sub-study from the BALANCE Program Trial, we collected data from 359 patients with established cardiovascular disease. Plasma fatty acids and inflammatory biomarkers (interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, high sensitive C-reactive protein (hs-CRP), adiponectin, and tumor necrosis factor (TNF)-alpha) were measured. Biomarkers and plasma fatty acid levels of subjects across insulin resistant and not insulin resistant groups were compared, and general linear models were used to examine the association between plasma fatty acids and inflammatory biomarkers.
resultsSubjects with insulin resistance had a higher concentration of hs-CRP (p = 0.002) and IL-6 (p = 0.002) than subjects without insulin resistance. Among subjects without insulin resistance there was a positive association between stearic fatty acid and IL-6 (p = 0.032), and a negative association between alpha-linolenic fatty acid and pro-inflammatory biomarkers (p < 0.05). Among those with insulin resistance there was a positive association between monounsaturated fatty acids and arachidonic fatty acid and adiponectin (p < 0.05), and a negative association between monounsaturated and polyunsaturated fatty acids and pro-inflammatory biomarkers (p < 0.05), as well as a negative association between polyunsaturated fatty acids and adiponectin (p < 0.05). Our study has not found any association between hs-CRP and plasma fatty acids.
conclusionsSubjects in secondary prevention for cardiovascular disease with insulin resistance have a higher concentration of hs-CRP and IL-6 than individuals without insulin resistance, and these inflammatory biomarkers are positively associated with saturated fatty acids and negatively associated with unsaturated fatty acids.
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