Evidence map›Paper›PMID 29466956›Full record

ArticleBMC infectious diseases2018

Outcome and prognostic factors of patients with right-sided infective endocarditis requiring intensive care unit admission.

Hugues Georges, Olivier Leroy, Norair Airapetian, Nicolas Lamblin, Elie Zogheib, Patrick Devos, Sebastien Preau, Hauts de France endocarditis study group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  8. The pivotal role of cardiac computed tomography angiogram andEuropean heart journal. Case reports · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hugues GeorgesService de Réanimation Médicale et Maladies Infectieuses, Hôpital Chatiliez, 135 rue du Président, 59200, Tourcoing, France. hgeorges@ch-tourcoing.fr.
Olivier LeroyService de Réanimation Médicale et Maladies Infectieuses, Hôpital Chatiliez, 135 rue du Président, 59200, Tourcoing, France.
Norair AirapetianRéanimation polyvalente, CHU Amiens Picardie, Amiens, France.
Nicolas LamblinPôle de cardiologie, Hôpital cardio-thoracique, CHU Lille, Avenue du Professeur E. Laine, 59037, Lille Cedex, France.
Elie ZogheibRéanimation polyvalente, CHU Amiens Picardie, Amiens, France.
Patrick DevosUniversité LILLE. EA 2694 - Santé publique : Epidémiologie et qualité des soins, CHU de Lille, 59000, Lille, France.
Sebastien PreauPôle de réanimation, Hôpital R. Salengro, CHU de Lille, Avenue du Professeur E. Laine, 59000, Lille Cedex, France.
Hauts de France endocarditis study group
Centre Hospitalier Universitaire de Lille · FRCentre Hospitalier de Tourcoing · FRCentre Hospitalier Universitaire Amiens-Picardie · FRUniversité de Lille · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRight-sided infective endocarditis (RSIE) is an uncommon diagnosis accounting for less than 10% of cases of infective endocarditis. Optimal management for severely ill patients with RSIE remains challenging because few studies reported on management and outcome. The goal of our study was to determine outcome and associated prognostic factors in a population of ICU patients with a diagnosis of definite, active and severe RSIE.

methodsWe performed a retrospective study in 10 French ICUs between January 2002 and December 2012. Main outcome was mortality at 30 days after ICU admission. Significant variables associated with 30-days mortality in the bivariate analysis were included in a logistic regression analysis.

resultsA total of 37 patients were studied. Mean age was 47.9 ± 18.4 years. Mean SAPS II, SOFA score and Charlson comorbidity index were 32.4 ± 17.4, 6.3 ± 4.4 and 3.1 ± 3.4, respectively. Causative pathogens, identified in 34 patients, were mainly staphylococci (n = 29). The source of endocarditis was a catheter related infection in 10 patients, intravenous drug abuse in 8 patients, cutaneous in 7 patients, urinary tract related in one patient and has an unknown origin in 7 patients. Vegetation size was higher than 20 mm for 14 patients. Valve tricuspid regurgitation was classified as severe in 11 patients. All patients received initial appropriate antimicrobial therapy. Aminoglycosides were delivered in combination with β-lactam antibiotics or vancomycin in 22 patients. Surgical procedure was performed in 14 patients. Eight patients (21.6%) died within 30 days following ICU admission. One independent prognostic factor was identified: use of aminoglycosides was associated with improved outcome (OR = 0.1; 95%CI = 0.0017-0.650; p = 0.007).

conclusionMortality of patients with RSIE needing ICU admission is high. Aminoglycosides used in combination with β-lactam or vancomycin could reduce 30 days mortality.

Indexed as

AdultAgedAminoglycosidesAnti-Bacterial AgentsBacteriocinsCatheter-Related InfectionsEndocarditisFemaleHospitalizationHumansIntensive Care UnitsLogistic ModelsMaleMiddle AgedPrognosisRetrospective StudiesAminoglycosidesAnti-Bacterial AgentsBacteriocinsstaphylococcinVancomycinIntensive care unitPrognostic factorsRight-sided infective endocarditis

Identifiers

PMID29466956
PMCPMC5822595
OpenAlexW2806686420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.