ArticleAnnals of neurology2018
Memory complaints, dementia, and neuropathology in older blacks and whites.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 57 citations in OpenAlex.
- A world view: Considerations of sociocultural diversity in the study of subjective cognitive decline in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Associations between subjective cognitive concern, brain network connectivity, and cognitive performance in cognitively normal older adults.Aging brain · 2026Article
- Alzheimer's Disease DNA Methylation Index (AD-DMI) and its Association with Late-Life Cognitive Function.NPJ dementia · 2026Article
- Association of Subjective Memory Complaints With Neuropathologic Changes at Age 90 or Older: The 90+ Study.Neurology · 2025Article
- Association of subjective memory complaints with serum biomarkers of neurodegeneration and cognition: A population-based study.Journal of the American Geriatrics Society · 2025Article
- Vascular risk factor associations with subjective cognitive decline and mild behavioural impairment.Brain communications · 2025Article
- Limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) is associated with abnormalities in white matter structural integrity and connectivity: An ex-vivo diffusion MRI and pathology investigation.Neurobiology of aging · 2024Article
- Guideline for the cognitive assessment and follow-up in the Guangdong-Hong Kong-Macao Greater Bay Area (2024 edition).Aging medicine (Milton (N.S.W)) · 2024Article
- Self- and interviewer-reported cognitive problems in relation to cognitive decline and dementia: results from two prospective studies.BMC medicine · 2024Article
- Does the Cognitive Change Index Predict Future Cognitive and Clinical Decline? Longitudinal Analysis in a Demographically Diverse Cohort.Journal of Alzheimer's disease : JAD · 2024Article
- Review
- Within-person associations between alcohol use and memory lapses among middle-aged and older adults.Drug and alcohol review · 2023Article
- Subjective Memory Decline Predicts Incident Cognitive Impairment Among White-But Not Black or Hispanic-Older Adults.The Gerontologist · 2023Article
- Association of vascular and degenerative brain pathologies and past medical history from the National Alzheimer's Coordinating Center Database.Journal of neuropathology and experimental neurology · 2023Article
- Subjective Cognitive Decline Is Associated With Lower Baseline Cognition and Increased Rate of Cognitive Decline.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Association of Subjective Cognitive Decline With Progression to Dementia in a Cognitively Unimpaired Multiracial Community Sample.Neurology · 2023Article
- Psychosocial Factors Associated with Memory Complaints during the First Wave of the COVID-19 Pandemic: A Multi-Country Survey.Brain sciences · 2023Article
- Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study.BMJ (Clinical research ed.) · 2023Article
- Subjective cognitive decline is a better marker for future cognitive decline in females than in males.Alzheimer's research & therapy · 2022Article
- Identification of Dementia in Recent Medicare Claims Data, Compared With Rigorous Clinical Assessments.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine relationships of memory complaints to cognitive function and decline, incident dementia, and neurodegenerative and other neuropathologies, as well as the population-attributable risk for dementia in older black and white persons.
methodsA total of 4,015 community-based persons (28% black; 74% women; mean baseline age = 78 years) were enrolled in 1 of 4 longitudinal cohort studies, and another 2,937 in a population-based cohort. Memory scores, assessed using 2 questions (5-point Likert scales) were categorized as complaints present or absent. Global cognition and 5 cognitive domains were derived from annual neuropsychological tests. Dementia was assessed from these tests and additional data. Neuropathologic data were available for 1,350 deceased subjects with brain autopsies. Regression and mixed effects models were used to examine relationships of memory complaints to cognition and neuropathology.
resultsBaseline memory complaints (n = 1,310; 33% of 4,015) were associated with lower cognition and faster decline in all domains (global score estimate = -0.032, standard error = 0.004, p < 0.0001), during a mean follow-up of 6 (standard deviation = 2) years. Persons with memory complaints had higher dementia risk (hazard ratio = 1.64, 95% confidence interval [CI] = 1.42-1.89) and odds of pathologic Alzheimer disease (odds ratio [OR] = 1.96, 95% CI = 1.51-2.54), neocortical Lewy bodies (OR = 2.47, 95% CI = 1.54-3.96), and other neurodegenerative pathologies. Results for dementia risk were similar among blacks and whites. Among 2,937 older persons in a population-based cohort with similar data, the population-attributable risk for incident dementia due to memory complaints was 14.0% (95% CI = 2.6-23.0), and did not vary between the black and white groups.
interpretationMemory complaints are common in older black and white persons, and relate to cognitive decline, dementia risk, and neurodegenerative pathologies. Ann Neurol 2018;83:718-729.
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