Evidence map›Paper›PMID 29466766›Full record

ReviewLeukemia research2018

Recent advances in the genomics and therapy of BCR/ABL1-positive and -negative chronic myeloproliferative neoplasms.

Tariq I Mughal, Jason Gotlib, Ruben Mesa, Steffen Koschmieder, H Jean Khoury, Jorge E Cortes, Tiziano Barbui, Rüdiger Hehlmann, Michael Mauro, Susanne Saussele and 6 more

Open access · greenAbstract readReview
In one paragraph

Review in Leukemia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 12 institutions in 4 countries.

Tariq I MughalTufts University Medical Center, Boston, MA, USA. Electronic address: tariq.mughal@tufts.edu.
Jason GotlibStanford Cancer Institute, Stanford, CA, USA.
Ruben MesaUT Health San Antonio Cancer Center, San Antonio, TX, USA.
Steffen KoschmiederFaculty of Medicine, RWTH Aachen University, Aachen, Germany.
H Jean KhouryEmory University, Atlanta, GA, USA.
Jorge E CortesMD Anderson Cancer Center, Houston, TX, USA.
Tiziano BarbuiPapa Giovani XXIII Hospital and Research Center, Bergamo, Italy.
Rüdiger HehlmannUniversität Heidelberg, Mannheim, Germany.
Michael MauroMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Susanne SausseleUniversität Heidelberg, Mannheim, Germany.
Jerald P RadichFredreick Hutchinson Cancer Research Center, Seattle, WA, USA.
Richard A Van EttenUniversity of California Irvine, Irvine, CA, USA.
Giuseppe SaglioOrbassano University Hospital, Turin, Italy.
Srdnan VerstovekMD Anderson Cancer Center, Houston, TX, USA.
Robert Peter GaleImperial College London at Hammersmith Hospital, London, UK.
Omar Abdel-WahabMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Heidelberg University · DEMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USEmory University · USFred Hutch Cancer Center · USHammersmith Hospital · GBMays Cancer Center at UT Health San AntonioOspedale Papa Giovanni XXIII · ITRWTH Aachen University · DEStanford Cancer InstituteUniversity Medical Center · USUniversity of California, Irvine · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robin Jean Leach · 1991 to 2026
$59.1M
NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA054174
6 · The paper itself

Abstract

This review is based on the presentations and deliberations at the 7th John Goldman Chronic Myeloid Leukemia (CML) and Myeloproliferative Neoplasms (MPN) Colloquium which took place in Estoril, Portugal on the 15th October 2017, and the 11th post-ASH International Workshop on CML and MPN which took place on the 6th-7th December 2016, immediately after the 58th American Society of Hematology Annual Meeting. Rather than present a resume of the proceedings, we have elected to address some of the topical translational research and clinically relevant topics in greater detail. We address recent updates in the genetics and epigenetics of MPN, the mechanisms of transformation by mutant calreticulin, advances in the biology and therapy of systemic mastocytosis, clinical updates on JAK2 inhibitors and other therapeutic approaches for patients with MPNs, cardiovascular toxicity related to tyrosine kinase inhibitors and the concept of treatment-free remission for patients with CML.

Indexed as

Antineoplastic AgentsCalreticulinCardiovascular DiseasesCell Transformation, NeoplasticChronic DiseaseCongresses as TopicEpigenesis, GeneticFusion Proteins, bcr-ablHumansJanus Kinase 2Mastocytosis, SystemicMutationMyeloproliferative DisordersProtein Kinase InhibitorsRemission InductionStaurosporineAntineoplastic AgentsBCR-ABL1 fusion protein, humanCalreticulinCALR protein, humanFusion Proteins, bcr-ablJAK2 protein, humanJanus Kinase 2midostaurinProtein Kinase InhibitorsStaurosporineCALRCardiotoxicityCMLJAK2 inhibitorsMastocytosisMPNTFR

Identifiers

PMID29466766
PMCPMC6613209
OpenAlexW2791613076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.