ArticleCell reports2018
Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance.
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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69citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
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Who cites it
69 citing papers in PubMed, 109 citations in OpenAlex.
- miR-27a Suppresses Mitochondrial Function to Promote Hepatic Steatosis in High-Fat-Diet-Induced Obesity.Molecules (Basel, Switzerland) · 2026Article
- Non-coding RNAs in lipid metabolism and their roles in atherosclerosis.Nature reviews. Cardiology · 2026Review
- Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives.Journal of atherosclerosis and thrombosis · 2026Review
- miRNAs, lncRNAs, circRNAs and piRNAs in Nonalcoholic Fatty Liver Disease: Past, Present and Future.International journal of molecular sciences · 2025Review
- Genomic medicine in hepatology: mechanisms and liver treatment strategies.Molecular medicine (Cambridge, Mass.) · 2025Review
- Involvement of miRNAs in the Cluster of Metabolic Factors of MetS: Nutrition-Genome-MetS Axis.Journal of clinical medicine · 2025Review
- Therapeutic Applications of Poly-miRNAs and miRNA Sponges.International journal of molecular sciences · 2025Review
- Exploring serum miR-33b as a novel diagnostic marker for hypercholesterolemia and obesity: insights from a pilot case-control study.BMC endocrine disorders · 2025Article
- Review
- Resveratrol suppresses hepatic fatty acid synthesis and increases fatty acid β-oxidation via the microRNA-33/SIRT6 signaling pathway.Experimental and therapeutic medicine · 2024Article
- Roles and Mechanisms of miRNAs in Abdominal Aortic Aneurysm: Signaling Pathways and Clinical Insights.Current atherosclerosis reports · 2024Review
- Analysis of Circulating miRNA Expression Profiles in Type 2 Diabetes Patients with Diabetic Foot Complications.International journal of molecular sciences · 2024Article
- microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.Nature communications · 2024Article
- Adipose tissue lipid metabolism: lipolysis.Current opinion in genetics & development · 2023Review
- MicroRNAs and Nonalcoholic Steatohepatitis: A Review.International journal of molecular sciences · 2023Review
- Targeted Expression to Liver of an antimiR-33 Sponge as a Gene Therapy Strategy against Hypercholesterolemia: In Vitro Study.Current issues in molecular biology · 2023Article
- Circulating and Exosomal microRNA-33 in Childhood Obesity.Biomedicines · 2023Article
- Biomarkers of obesity-mediated insulin resistance: focus on microRNAs.Diabetology & metabolic syndrome · 2023Review
- Effects of miR-33 Deficiency on Metabolic and Cardiovascular Diseases: Implications for Therapeutic Intervention.International journal of molecular sciences · 2023Review
- Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2023Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 3 institutions in 1 country.
Nathan L PriceVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Abhishek K SinghVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Noemi RotllanVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Leigh GoedekeDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Allison WingIntegrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, CT, USA.
Alberto Canfrán-DuqueVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Alberto Diaz-RuizTranslational Gerontology Branch, National Institute of Aging, NIH, Baltimore, MD, USA.
Elisa AraldiVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Ángel BaldánEdward A. Doisy Department of Biochemistry and Molecular Biology and Center for Cardiovascular Research, Saint Louis University School of Medicine, St. Louis, MO, USA.
Joao-Paulo CamporezDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Yajaira SuárezVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.
Matthew S RodehefferIntegrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, CT, USA.
Gerald I ShulmanDepartment of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Cellular and Molecular Physiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA.
Rafael de CaboTranslational Gerontology Branch, National Institute of Aging, NIH, Baltimore, MD, USA.
Carlos Fernández-HernandoVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA; Integrative Cell Signaling and Neurobiology of Metabolism Program, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: carlos.fernandez@yale.edu.
Yale University · USNational Institute on Aging · USSaint Louis University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MSkill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0MCalorie restriction and agingZIAAG000368 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$6.9MNovel insights into the molecular and cellular mechanism regulating lipid metabolism and atherosclerosisR35HL135820 · NHLBI · YALE UNIVERSITY · PI FERNANDEZ HERNANDO, CARLOS · 2017 to 2023
$6.0MMechanisms of Lipid-Induced Hepatic Insulin ResistanceR01DK040936 · NIDDK · YALE UNIVERSITY · PI SHULMAN, GERALD I · 1989 to 2015
$5.1MCellular & molecular mechanisms of white adipose tissue mass regulationR01DK090489 · NIDDK · YALE UNIVERSITY · PI RODEHEFFER, MATTHEW S · 2011 to 2020
$3.8MmicroRNAs in vascular diseasesR01HL105945 · NHLBI · YALE UNIVERSITY · PI SUAREZ, YAJAIRA · 2011 to 2020
$3.7MControl Sterol and Lipoprotein Homeostasis by miRNAR01HL107794 · NHLBI · SAINT LOUIS UNIVERSITY · PI BALDAN, ANGEL · 2011 to 2019
$3.3MHL-Regulation of Angiogenesis in the Obese Adipose Tissue by Secreted microRNAsR01HL135012 · NHLBI · YALE UNIVERSITY · PI SUAREZ, YAJAIRA · 2017 to 2020
$2.1MNCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL105945NHLBI NIH HHS R01 HL107794NHLBI NIH HHS R01 HL135012NHLBI NIH HHS R35 HL135820NIDDK NIH HHS R01 DK040936NIDDK NIH HHS R01 DK090489NIGMS NIH HHS T32 GM007223
Abstract
While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovascular diseases. However, the deleterious effects of long-term anti-miR-33 therapies and predisposition of miR-33
Indexed as
Gene DeletionAdipose TissueAdiposityAnimalsCholesterol, HDLCholesterol, LDLEatingEnzyme ActivationGene Expression RegulationGenetic Predisposition to DiseaseGerm CellsInflammation MediatorsInsulin ResistanceLipid MetabolismLiverMice, Inbred C57BLCholesterol, HDLCholesterol, LDLInflammation MediatorsMicroRNAsMirn33 microRNA, mouseProtein Kinase C-epsilonSterol Regulatory Element Binding Protein 1adipocytediabetesfood-consumptioninsulin-resistancemetabolismmicro-RNAmiR-33obesitypair-feeding
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