Evidence map›Paper›PMID 29466738›Full record

ArticleCell reports2018

Cry2 Is Critical for Circadian Regulation of Myogenic Differentiation by Bclaf1-Mediated mRNA Stabilization of Cyclin D1 and Tmem176b.

Matthew Lowe, Jacob Lage, Ellen Paatela, Dane Munson, Reilly Hostager, Ce Yuan, Nobuko Katoku-Kikyo, Mercedes Ruiz-Estevez, Yoko Asakura, James Staats and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 67 citations in OpenAlex.

  1. Article
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  4. New insights into the skeletal muscle circadian clock in ruminants.Journal of animal science and biotechnology · 2026
    Review
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  11. Ablation of satellite cell-specific clock gene, Bmal1, alters force production, muscle damage, and repair following contractile-induced injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Matthew LoweStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development , University of Minnesota, Minneapolis, MN 55455, USA.
Jacob LageStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development , University of Minnesota, Minneapolis, MN 55455, USA.
Ellen PaatelaStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA.
Dane MunsonStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA.
Reilly HostagerStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA.
Ce YuanStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Bioinformatics and Computational Biology Graduate Program , University of Minnesota, Minneapolis, MN 55455, USA.
Nobuko Katoku-KikyoStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Neurology , University of Minnesota, Minneapolis, MN 55455, USA.
Mercedes Ruiz-EstevezStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development , University of Minnesota, Minneapolis, MN 55455, USA.
Yoko AsakuraStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development , University of Minnesota, Minneapolis, MN 55455, USA.
James StaatsStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development , University of Minnesota, Minneapolis, MN 55455, USA.
Mulan QaharStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Neurology , University of Minnesota, Minneapolis, MN 55455, USA.
Michaela LohmanStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA.
Atsushi AsakuraStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Neurology , University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: asakura@umn.edu.
Nobuaki KikyoStem Cell Institute , University of Minnesota, Minneapolis, MN 55455, USA; Department of Genetics, Cell Biology, and Development , University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: kikyo001@umn.edu.
University of Minnesota · US

Funding

Genetically Engineered Muscle Stem Cell Transplantation for Muscular Dystrophy...R01AR062142 · NIAMS · UNIVERSITY OF MINNESOTA · PI ASAKURA, ATSUSHI · 2012 to 2016
$1.6M
Histone isomerization and pluripotencyR01GM098294 · NIGMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2012 to 2015
$1.1M
Transcriptional elongation and long noncoding RNAR21HD083648 · NICHD · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2016 to 2017
$408k
Engineering iPSC-Derived Skeletal Muscle and Cells for TransplantationR21AR070319 · NIAMS · UNIVERSITY OF MINNESOTA · PI ASAKURA, ATSUSHI · 2016 to 2017
$372k
Long Noncoding RNA and MyogenesisR21AR066158 · NIAMS · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2015 to 2016
$368k
Hypoxia and long noncoding RNAR21CA187232 · NCI · UNIVERSITY OF MINNESOTA · PI KIKYO, NOBUAKI · 2014 to 2015
$364k
NCI NIH HHS R21 CA187232NIAMS NIH HHS R01 AR062142NIAMS NIH HHS R21 AR066158NIAMS NIH HHS R21 AR070319NICHD NIH HHS R21 HD083648NIGMS NIH HHS R01 GM098294
6 · The paper itself

Abstract

Circadian rhythms regulate cell proliferation and differentiation; however, little is known about their roles in myogenic differentiation. Our synchronized differentiation studies demonstrate that myoblast proliferation and subsequent myotube formation by cell fusion occur in circadian manners. We found that one of the core regulators of circadian rhythms, Cry2, but not Cry1, is critical for the circadian patterns of these two critical steps in myogenic differentiation. This is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion. Myoblasts lacking Cry2 display premature cell cycle exit and form short myotubes because of inefficient cell fusion. Consistently, muscle regeneration is impaired in Cry2

Indexed as

Cell DifferentiationCircadian RhythmMuscle DevelopmentAnimalsCell CycleCell FusionCell LineCryptochromesCyclin D1Gene Expression RegulationMembrane ProteinsMice, KnockoutMusclesMyoblastsRegenerationRepressor ProteinsBclaf1 protein, mouseCry1 protein, mouseCry2 protein, mouseCryptochromesCyclin D1Membrane ProteinsRepressor ProteinsRNA, MessengerTmem176B protein, mouseBclaf1cell cyclecell fusioncircadian rhythmCry1Cry2cyclin D1muscle differentiationmuscle regenerationTmem176b

Identifiers

PMID29466738
PMCPMC5849083
OpenAlexW2787954248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.