ArticleNature2018
Electromechanical vortex filaments during cardiac fibrillation.
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
85 citing papers in PubMed, 165 citations in OpenAlex.
- Real-time GPU-accelerated coupled cardiac system: Integrating bidirectional interactions between living optogenetic monolayers and computational simulations.PLoS computational biology · 2026Article
- Discovering Interpretable Semantics from Radio Signals for Contactless Cardiac Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Panoramic voltage-sensitive optical mapping of contracting hearts using cooperative multiview motion tracking with 12 cameras.The Journal of physiology · 2026Article
- Understanding Atrial Fibrillation Complexity Through the Lens of Turbulence Dynamics: Implications for Treatment Strategies.Journal of cardiovascular electrophysiology · 2026Review
- Contactless 12-lead electrocardiogram via deep computational radar.npj biomedical innovations · 2026Article
- The turbulent brain: Modeling vortex interactions for understanding human cognition.Network neuroscience (Cambridge, Mass.) · 2026Article
- Mechanistic interpretations of sustained ventricular fibrillation: The role of mapping methodology, model and time.Heart international · 2026Review
- Topology in Thermal, Particle, and Plasma Diffusion Metamaterials.Chemical reviews · 2025Review
- Spiral defect chaos with intermittency increases mean termination time.Physical review. E · 2025Article
- Neuronal synchronization iniScience · 2025Article
- Spatiotemporal dynamics of sleep spindles form spiral waves that predict overnight memory consolidation and age-related memory decline.Communications biology · 2025Article
- Control of cardiac waves in human iPSC-CM syncytia by a Halbach array and magnetic nanoparticles.Biophysical journal · 2025Article
- Prediction of excitable wave dynamics using machine learning.Chaos, solitons, and fractals · 2025Article
- A topological hypothesis for atrial fibrilllation, atrial flutter and focal atrial tachycardia: comparison and contrast with Kosterlitz-Thouless physics.Frontiers in network physiology · 2025Article
- Evidence of universal conformal invariance in living biological matter.Nature physics · 2025Article
- VizCOM: A Novel Tool for Advanced Visualization and Analysis of Cardiac Optical Mapping Data.Computing in cardiology · 2025Article
- Analysis of complex excitation patterns using Feynman-like diagrams.Scientific reports · 2024Article
- Dreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models.APL machine learning · 2024Article
- Arrhythmogenic Potential of Myocardial Edema: The Interstitial Osmolality Induces Spiral Waves and Multiple Excitation Wavelets.Biomedicines · 2024Article
- Reconstruction of excitation waves from mechanical deformation using physics-informed neural networks.Scientific reports · 2024Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The self-organized dynamics of vortex-like rotating waves, which are also known as scroll waves, are the basis of the formation of complex spatiotemporal patterns in many excitable chemical and biological systems. In the heart, filament-like phase singularities that are associated with three-dimensional scroll waves are considered to be the organizing centres of life-threatening cardiac arrhythmias. The mechanisms that underlie the onset, maintenance and control of electromechanical turbulence in the heart are inherently three-dimensional phenomena. However, it has not previously been possible to visualize the three-dimensional spatiotemporal dynamics of scroll waves inside cardiac tissues. Here we show that three-dimensional mechanical scroll waves and filament-like phase singularities can be observed deep inside the contracting heart wall using high-resolution four-dimensional ultrasound-based strain imaging. We found that mechanical phase singularities co-exist with electrical phase singularities during cardiac fibrillation. We investigated the dynamics of electrical and mechanical phase singularities by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart. We show that cardiac fibrillation can be characterized using the three-dimensional spatiotemporal dynamics of mechanical phase singularities, which arise inside the fibrillating contracting ventricular wall. We demonstrate that electrical and mechanical phase singularities show complex interactions and we characterize their dynamics in terms of trajectories, topological charge and lifetime. We anticipate that our findings will provide novel perspectives for non-invasive diagnostic imaging and therapeutic applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.